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R. Loch Macdonald, MD, PhD
 CURRICULUM VITAE
Name: Robert Loughlin Macdonald
Place of Birth: Eugene, Oregon
Citizenship: United States, Canada
Family:
Married to Sheilah Stedman, 3 children (Iain Alexander 1989, Robyn Lindsay 1991, Erin Lea 1994)
Home Address:
4936 South Kimbark Avenue
Chicago, Illinois, 60615, USA
Phone: (+1-773) 924-9548
Work Address:
Section of Neurosurgery, MC 3026
University of Chicago Medical Center
5841 South Maryland Avenue
Chicago, Illinois, 60637, USA
Phone: (01-773) 702-2123
Fax (01-773) 702-3518
E mail: rlmacdon@uchicago.edu
Education:
" 6 Undergraduate scholarships for academic performance, University of British Columbia, Vancouver, British Columbia, Canada Faculty of Science, 1978-1981
" M.D., University of British Columbia, Vancouver, British Columbia, Canada, 1985
" Prizes for highest academic standing in anatomy, biochemistry, and pathology, 6 scholarships for academic performance, University of British Columbia Faculty of Medicine
" Rotating Internship, University of Toronto, St. Michael's Hospital, 1986
" Ph.D., (Experimental Surgery), University of Alberta, Edmonton, Alberta, Canada, 1991, Dissertation: "Mechanisms of Cerebral Vasospasm Following Subarachnoid Hemorrhage in Monkeys" (Research Advisor - Bryce Weir)
" Neurosurgery residency, University of Toronto, Toronto, Ontario, Canada, 1993, training at St. Michael's, Toronto Western and Toronto General Hospitals, Sunnybrook Medical Center and the Hospital for Sick Children
" 2nd Annual International Symposium and Hands-On Course on Cerebral Revascularization, November 30 - December 2, 2001, St. Louis, Missouri
Academic Appointments
" 9/92 - 4/93 - Neurosurgery Fellow, University of Toronto, Toronto, Ontario, Canada
" 4/93 - Assistant Professor, Department of Surgery (Neurosurgery) and Attending Neurosurgeon, University of Chicago Medical Center
" 4/00 - Associate Professor, Department of Surgery (Neurosurgery) and Attending Neurosurgeon, University of Chicago Medical Center
" 1/97 - Attending Neurosurgeon, Louis A. Weiss Memorial Hospital
" 4/00 - Associate Professor, Department of Radiation and Cellular Oncology
" 1/00 - 8/03 - Program director, Neurosurgery residency
" 4/02 - Committee on Molecular Medicine, University of Chicago Division of Biological Sciences
" 6/03 - Professor, Departments of Surgery (Neurosurgery) and Radiation and Cellular Oncology, University of Chicago
Licensure and Certification
o 1986 - Diploma, National Board of Medical Examiners of the U.S.A.
o 9/92 - F.R.C.S.(C), Fellow of the Royal College of Surgeons of Canada (Neurosurgery) and Certificate in Neurosurgery
o 4/93 - Illinois Medical Licensure 003-036-057379-01
o 11/95 - Board Certification in Neurosurgery, American Board of Neurological Surgeons
o 10/95 - Fellow, American College of Surgeons
Awards and Other Scientific Recognition
" 1985 - Medical School Silver medal - University of British Columbia Faculty of Medicine
" 1989 - AW Harrison Resident Teaching Award - Sunnybrook Medical Center
" 1990 - First Prize, University of Alberta Surgical Resident Research Day
" 1990 - Morley Prize - University of Toronto Division of Neurosurgery
" 1991 - K.G. MacKenzie Prize - Canadian Congress of Neurological Sciences
" 1991 - Proxime Accessit, Syntex Prize Essay
" 1991 - Resident Publication Prize - University of Alberta Faculty of Medicine
" 1993 - Ciba-Giegy Prize - Canadian Journal of Neurological Sciences
" 1994 - Best Poster, Cerebrovascular Section, 44th Annual Meeting of the Congress of Neurological Surgeons
" 2003 - President, 8th International Conference on Cerebral Vasospasm
Memberships in Professional Societies
o 1992 - Royal College of Surgeons of Canada
o 1993 - Canadian Neurosurgical Society
o 1994 - Chicago Medical Association
o 1994 - Illinois Medical Association
o 1994 - American Medical Association
o 1994 - Chicago Neurological Society
o 1994 - 1999 - The Oxygen Society
o 1994 - Joint Section on Cerebrovascular Surgery of the American Association of Neurological
Surgeons and the Congress of Neurological Surgeons
o 1994 - 1999 American Association for the Advancement of Science
o 1995 - Congress of Neurological Surgeons
o 1995 - American Association of Neurological Surgeons
o 1996 - American College of Surgeons
o 2000 - American Academy of Neurological Surgery
o 2001 - Stroke Council, American Heart Association
o 2002 - Society of Neurological Surgeons
Fields of Specialization
Research - Basic mechanisms of contraction of vascular smooth muscle by blood and hemoglobin, cerebral vasospasm after subarachnoid hemorrhage, mechanisms of intimal proliferation and thrombosis of arteriovenous fistulas
Clinical - Cerebrovascular surgery, cerebral revascularization and extracranial-intracranial bypass surgery, carotid artery disease, cerebral aneurysms, subarachnoid hemorrhage, vasospasm, brain vascular malformations, arteriovenous malformations, cavernous malformations, arteriovenous fistulas, carotid endarterectomy, intracranial surgery, brain tumors, meningiomas, gliomas
Committees:
o 1993 - 96 - Member, Critical Care Committee, University of Chicago Hospitals
o 1995 - Member, Radiology Task Force, University of Chicago Hospitals
o 1995 - Member, Department of Surgery Research Committee
o 1996 - Chairman, Critical Care Committee, University of Chicago Hospitals
o 1996 - Member, Quality Improvement Committee, University of Chicago Hospitals
o 1997 - Member, International Scientific Advisory Committee, 6th International Symposium on Cerebral Vasospasm, Sydney, Australia
o 1998 - 1999 - Member, International Scientific Advisory Committee, World Federation of Interventional and Therapeutic Neuroradiology, Algarve, Portugal
o 1999 - 2000 - Member, International Scientific Advisory Committee, 7th International Symposium on Cerebral Vasospasm, Interlaken, Switzerland
o 1999 - Chairman, Department of Surgery Research Committee
o 1999 - 2000 - Member, Scientific Program Committee, Congress of Neurological Surgeons Annual Meeting, San Antonio, TX, 2000
o 1999 - 2000 - Director, Practical Courses, Congress of Neurological Surgeons Annual Meeting, San Antonio, TX, 2000
o 2000 - Scientific Committee, First Joint American - Japanese meeting for Surgical and Endovascular Treatment of Cerebrovascular Disorders
o 2000 - 2003 - Abstract Grading Subcommittee, 26th International Stroke Conference
o 2002 - Chair, International Advisory Board on the Development of Fasudil, Berlex, Specialized Therapeutics and Schering AG Pharmaceuticals
o 2003 - Member, Protocol Advisory Board, Axovan Pharmaceuticals
o 2003 - President and organizer, 8th International Conference on Cerebral Vasospasm, Chicago, IL, 2003
Research Support
Past
o Alberta Heritage Foundation for Medical Research, Research Fellowship, "Role of Hemoglobin in Cerebral Vasospasm", $36,000/year direct, 7/89 - 6/90, 7/90 - 6/91
o Physicians' Services Incorporated Foundation, Principal Investigator, "Effect of Transluminal Angioplasty on Vasospasm in Dogs", $24,000/year direct, 7/92 - 6/93
o Brain Research Foundation, Principal Investigator, "Pathogenesis of Cerebral Vasospasm in Dogs", $9500/year direct, 1993
o American Association of Neurological Surgeons, Young Clinician Investigator Award, "Role of Free Radicals in the Pathogenesis of Vasospasm Following Subarachnoid Hemorrhage", $40,000/year direct, 1/94 - 12/95
o American Heart Association, Studentship Faculty Sponsor (Hongskik Han), "Role of Heme Oxygenase-1 in Vasospasm", $2000/year direct, 1994
o Howard Hughes Medical Institute Summer Undergraduate Research Fellowship, Faculty Sponsor (Bogdan Sima), "Mechanism of Acute Hemolysate Contraction of Cerebral Arteries", $3500/year direct, 1994
o Brain Research Foundation, Principal Investigator, "Role of Endothelin in Cerebral Vasospasm", $10,000/year direct, 1994
o Hoffman-LaRoche Pharmaceuticals, Principal Investigator, "Bosentan for Vasospasm in Monkeys", $40,600/year direct, 7/94 - 6/95
o Surgical Research Committee, University of Chicago, Principal Investigator, "Role of Free Radicals in Cerebral Vasospasm", $25,000/year direct, 1995
o Parke Davis Pharmaceuticals, Principal Investigator, "Effect of PD156707 on Cerebral Vasospasm After Subarachnoid Hemorrhage in Dogs", $20,000/year direct, 1996
o American College of Surgeons Faculty Research Fellowship, "Role of Heme Oxygenase-1 in Vasospasm", $30,000/year direct, 7/96 - 6/98
o Brain Research Foundation, Principal Investigator, "Endothelin in a Rat Model of Cerebral Vasospasm", $9,500/year direct, 1996
o Surgical Research Committee, University of Chicago, Principal Investigator, "Gene Therapy of Vasospasm After Subarachnoid Hemorrhage in Rats", $25,000/year direct, 7/97 - 6/98
o Brain Research Foundation, Principal Investigator, "Role of ATP in Cerebral Vasospasm", $10,000/year, 7/97 - 6/98
o American Heart Association, Studentship Faculty Sponsor (Jürgen Lüders), $2000/year direct, 1997
o N.I.H. RO1 NS28492, Center Investigator, "International Study of Unruptured Intracranial Aneurysms", 1/97 - 12/98
o N.I.H. KO8 NS01831, Principal Investigator, "Endothelin and Oxidant Stress in Vasospasm", $82,800/year direct, 9/96 - 7/00
o Surgery Research Committee, University of Chicago, Principal Investigator, "Gene Therapy for Obliteration of Arteriovenous Fistulas in Rats", $15,000/year direct, 7/98 - 6/99
o Brain Research Foundation, Principal Investigator, "Gene Therapy for Obliteration of Arteriovenous Fistulas in Rats", $14,000/year direct, 7/98 - 6/99
o Pharmacia-Upjohn, Principal Investigator, "Randomized Single Blind Study of Dalteparin versus Low Dose Heparin for Prevention of Thromboembolic Complications in Patients Undergoing Craniotomy", $30,000/year direct, 9/98-8/99
o American Association of Neurological Surgeons, Shirley L. Bagan Research Fellowship Faculty Sponsor (Babak Jahromi), "Electrophysiological Properties and Intracellular Ca2+ Homeostasis in Vasospastic Smooth Muscle", $35,000/year direct, 7/99 - 6/01
o American Heart Association, Principal Investigator, "Gene Therapy for Arteriovenous Fistulas in Rats", $66,500/year direct, 1/99 - 12/01
o Howard Hughes Medical Institute Summer Undergraduate Research Fellowship, Faculty Sponsor (George Weyer), "Role of Potassium Channels in Cerebral Vasospasm", $3500/year direct, 2002
o Howard Hughes Medical Institute Summer Undergraduate Research Fellowship, Faculty Sponsor (George Weyer), "Role of Inwardly-Rectifying Potassium Channels in Cerebral Vasospasm", $3500/year direct, 2003
Current
o Medical Research Council of Canada Research Fellowship, Faculty Sponsor (Babak Jahromi), "Mechanism of Prolonged Smooth Muscle Cell Contraction in Cerebral Vasospasm", $44,000/year direct (Cdn), 9/99 - 8/03
o American Heart Association Bugher Foundation Award for the Investigation of Stroke, Principal Investigator, "Role of Potassium Channels in Cerebral Vasospasm", $100,000/year direct, 1/02 - 12/05
o N.I.H. RO1, Principal Investigator, $400,000/year direct, "Pathophysiology of Chronic Cerebral Vasospasm", 7/02 - 6/07
Pending
o None
Editorial Boards and Reviewing:
o Ad hoc reviewer, Scanning Microscopy (1992), J Surg Res (1993, 1995), J Neurosurg (1993), Stroke (1993 - present), Neurosurgery (1994 - present), Hypertension in Pregnancy (1994), Free Rad Biol Med (1994, 1996), Surg Neurol (1994 - 1997, 1999 - present), Am J Physiol (1994-1996, 2002), Life Sci (1997), Biochem Biophys Acta (1999), J Neurosci Meth (2000), J Cereb Blood Flow Metab (2001, 2003), Am J Hum Genetics (2001), Lancet (2002)
o Grant reviewer, Physicians Services' Incorporated Foundation, 1993
o Reviewer, Institutional Animal Care and Use Committee Protocols, University of Chicago, Department of Surgery, 1993 - present
o Editorial Board, Neurosurgery, 1998 - present
o Grant reviewer, British Columbia Health Research Foundation, 1998
o Ad-hoc reviewer, N.I.H. Neurological Sciences and Disorders Study Section A, June, 1999
o Reviewer, N.I.H., Brain Disorders and Clinical Neurosciences Study Section 3, June, 2002 - June, 2003
o Ad-hoc reviewer, N.I.H., Brain Disorders and Clinical Neurosciences Study Section 2, July, 2002
o Editorial Board, Stroke, 2003 - present
o N.I.H. Study Section, Cell Death and Injury in Neurodegeneration, November, 2003 - present
Invited Lectures:
1. Invited Speaker, "Mechanisms of the Brain's Response to Subarachnoid Hemorrhage", Canadian Neurological Sciences Annual Meeting Neurobiology Review Course, Toronto, Canada (1993)
2. Invited Speaker, "Vasospasm, Aneurysms, Intra- and Postoperative Angiography", National Institutes of Health Section of Surgical Neurology, Bethesda, Maryland (1993)
3. Invited Speaker, "Pathogenesis of Cerebral Vasospasm", National Institutes of Health Section of Surgical Neurology, Bethesda, Maryland (1993)
4. Invited Lecturer, "Cerebral Vasospasm", University of Toronto, Division of Neurosurgery, Toronto, Canada (1994)
5. Moderator and presenter, "Cerebral Vasospasm Seminar", 1st Annual meeting of the Joint Section on Cerebrovascular Surgery, San Antonio (1996)
6. Invited Speaker, "Subarachnoid Hemorrhage", Luncheon seminar, 2nd Annual Meeting of the Section on Cerebrovascular Surgery of the AANS/CNS, Anaheim, California (1997)
7. Invited Speaker, "Pathogenesis of Cerebral Ischemia", 5th International Workshop on Cerebrovascular Surgery, Fukuoka, Japan (1997)
8. Invited Speaker, "Pathophysiology and Treatment of Cerebral Vasospasm", Chonbuk National Medical Center Department of Neurosurgery, Chonju, Korea (1997)
9. Invited Speaker, "Overview of Prevention of Vasospasm", 6th International Conference on Cerebral Vasospasm, Sydney, Australia (1997)
10. Invited Speaker, "Cerebral Blood Flow and Delayed Ischemic Deficit", 25th Annual Meeting of the Society of Neurosurgical Anesthesia and Critical Care, San Diego, California (1997)
11. Invited Speaker, "Basic Science of Cerebral Vasospasm", 75 Years of Neurosurgery in Canada, 1923-1998, Toronto, Canada (1998)
12. Invited Speaker, "Subarachnoid Hemorrhage", North American Stroke Meeting, Cancun, Mexico (1998)
13. Invited Presentation, "Spasmogens and Cerebral Vasospasm", Symposium on Stroke and Cerebral Vasospasm presented at the Internet World Congress in Biomedical Sciences, McMaster University, Hamilton, Canada (1998)
14. Invited Speaker, "Current Management of Aneurysmal Subarachnoid Hemorrhage", Neurosurgery Grand Rounds, University of Mississippi, Jackson, Mississippi (1999)
15. Invited Speaker, "Scientific Basis of Cerebral Vasospasm", 67th Annual Meeting of the American Association of Neurological Surgeons, New Orleans, Louisiana (1999)
16. Invited Speaker, "Molecular and Biological Basis of Arterial Vasospasm due to SAH", World Scientific Conference of the World Federation of Interventional and Therapeutic Neuroradiology, Algarve, Portugal (1999)
17. Invited Speaker, "Diagnosis and Management of Cerebral Vasospasm", Joint Meeting of the AANS/CNS Section on Cerebrovascular Surgery and the American Society of Interventional and Therapeutic Neuroradiology, New Orleans, Louisiana (2000)
18. Invited Speaker, "Studies on the Mechanism of Cerebral Vasospasm", Neurosurgery Research Conference, Department of Neurosurgery, University of Illinois at Chicago, Chicago, Illinois (2000)
19. Invited Speaker, "Cerebral Vasospasm", Breakfast seminar, 68th Annual Meeting of the American Association of Neurological Surgeons, San Francisco, California (2000)
20. Invited Lecture, "Pathophysiology and Molecular Genetics of Vasospasm", 7th International Conference on Cerebral Vasospasm, Interlaken, Switzerland (2000)
21. Moderator, "Experimental vasospasm", 7th International Conference on Cerebral Vasospasm, Interlaken, Switzerland (2000)
22. Participant, Panel Discussion, "From experimental to clinical vasospasm", 7th International Conference on Cerebral Vasospasm, Interlaken, Switzerland (2000)
23. Participant, Panel Discussion, "How should we prevent and treat vasospasm", 7th International Conference on Cerebral Vasospasm, Interlaken, Switzerland (2000)
24. Invited Speaker, "Current issues in the pathogenesis and management of vasospasm", Scientific symposium - Subarachnoid hemorrhage, 1st American-Japanese Meeting for Surgical and Endovascular Treatment of Cerebrovascular Disorders, Waikoloa, Hawaii (2001)
25. Moderator and presenter, "Critical care of cerebrovascular patients", 1st American-Japanese Meeting for Surgical and Endovascular Treatment of Cerebrovascular Disorders, Waikoloa, Hawaii (2001)
26. Invited Speaker, "Intracerebral hemorrhage", 70th Annual Meeting of the American Association of Neurological Surgeons, Toronto, Canada (2001)
27. Moderator, "Current management of vasospasm", 70th Annual Meeting of the American Association of Neurological Surgeons, Toronto, Canada (2001)
28. Invited Speaker, "Role of NO in vasospasm after experimental subarachnoid hemorrhage", 7th International Symposium on Resistance Arteries, Muskoka Sands, Ontario, Canada (2001)
29. Invited Speaker, "Current issues in the pathogenesis and management of vasospasm", 2001 Cerebrovascular Disease, Korean Society of Cerebrovascular Disease, Seoul, Korea (2001)
30. Invited Speaker, "Cerebral aneurysm surgery: Complication avoidance and management", 51st Annual Meeting of the Congress of Neurological Surgeons, San Diego, California (2001)
31. Invited Speaker, "Vasospasm after subarachnoid hemorrhage", Review and Update in Neuroscience for Neurosurgeons, Marine Biological Laboratory, Woods Hole, Massachusetts (2001)
32. Invited Speaker, "Decompressive craniectomy for ischemic stroke", 5th Joint Annual Meeting of the AANS/CNS Section on Cerebrovascular Surgery and the American Society of Interventional and Therapeutic Neuroradiology, Dallas, Texas (2002)
33. Invited Speaker, "Current management of subarachnoid hemorrhage and vasospasm", University of British Columbia,Vancouver, B.C., Canada (2002)
34. Moderator, "Treatment paradigm for vasospasm: Does anything work?", breakfast seminar at the 70th Annual Meeting of the American Association of Neurological Surgeons, Chicago, Illinois (2002)
35. Visiting Professor, "Potassium channel function in cerebral vasospasm", Stanford University Department of Neurosurgery, Palo Alto, California (2003)
36. Invited Speaker, "Pathophysiology of subarachnoid hemorrhage and vasospasm", Chicago Review Course in Neurosurgery, Chicago, Ilinois (2003)
37. Invited Speaker, "Pathophysiology and molecular genetics of vasospasm", luncheon seminar at the 6th Joint Annual Meeting of the AANS/CNS Section on Cerebrovascular Surgery and the American Society of Interventional and Therapeutic Neuroradiology, February 16-19, 2003, Phoenix, Arizona
38. Invited Speaker, "Management of complex intracranial aneurysms", luncheon seminar at the 32nd Annual Japanese Meeting of Surgery for Cerebral Stroke, March 14-15, 2003, Tokyo, Japan
39. Invited Speaker, "Subarachnoid hemorrhage management and outcome: Lessons from the Tirilazad database", invited lecture at the 32nd Annual Japanese Meeting of Surgery for Cerebral Stroke, March 14-15, 2003, Tokyo, Japan
40. Invited Speaker, "Neurosurgical education in the United States", invited lecture at Symposium on Neurosurgical Education, Tokyo Women's Medical University, March 16, 2003, Tokyo, Japan
41. Moderator, "Modern perspectives of treatment paradigms for vasospasm", breakfast seminar at the 71st Annual Meeting of the American Association of Neurological Surgeons, San Diego, California (2003)
42. Invited Speaker, "Perioperative management of subarachnoid hemorrhage: Improve postoperative outcomes", breakfast seminar at the 71st Annual Meeting of the American Association of Neurological Surgeons, San Diego, California (2003)
43. Discussant, "Clinical effectiveness of head-shaking method combined with cisternal irrigation using urokinase in preventing cerebral vasospasm following subarachnoid hemorrhage: Results of prospective controlled trial in 225 patients", 71st Annual Meeting of the American Association of Neurological Surgeons, San Diego, California (2003)
44. Invited Speaker, "Current management of subarachnoid hemorrhage and cerebral aneurysms", Weiss Hospital Grand Rounds, Chicago, Illinois (2003)
45. Moderator, "Clinical Treatment 1", 8th International Conference on Cerebral Vasospasm, Chicago, Illinois (2003)
Teaching:
o Year 2 Neuroanatomy course for University of Alberta Medical Students: University of Alberta, Edmonton, Alberta, Canada, September to December, 1990
o Director, Neurosurgery resident's weekly review course, University of Chicago, Department of Surgery, Section of Neurosurgery, 1993- present
o Instructor, Medical Student core lecture series, University of Chicago Pritzker School of Medicine, 1994 - 1997
o Instructor, Congress of Neurological Surgeons practical course: "Carotid Endarterectomy", October 2, 1994, September 29, 1996, September 27, 1997
o Summer undergraduate students and medical students supervised: Hongshik Han (1994), Bogdan Sima (1994-1995), John Kane (1994-1995), Brett Fenster (1995), Shahram Sepehri (1995), Andrew Kowalczuk (1996), George Lin (1996-1998), Emily Windmeyer (1996-1998), Jürgen Lüders (1997-1998), Iffat Ahmed (1998-2000), Gina DeGiovanni (1999-2000), David Rosen (2000-present), Kevin Smith (2000-2001), Dino Samartzis (1999-present), Tibor Boco (2001), George Weyer (2001-present), Erwin Krüger (2002-2003)
o Lecturer, Bioscience 247, "Animal Models of Human Disease", May 26, 2000, May 21, 2001, May 17, 2002, April 14, 2003
o Lecturer, Medical Neurobiology 305, "Subarachnoid Hemorrhage and Vasospasm", "Recovery and Regeneration after Brain Injury", 2 hours per year, May 18, June 1, 2001
o Assisted, with other members of the section of Neurosurgery, in the training of the following neurosurgeons at the University of Chicago: Spencer Block, M.D. (1993), Michael Sturgill, M.D. (1994), Vivekanand Palavali, M.D. (1995), Todd Alexander, M.D. (1996), Jonathan Citow, M.D. (1999), Taras Masnyk, M.D. (1999), Ilyas Munshi, M.D. (2000), Bahktiar Yamini, M.D. (2001), Daniel Curry, M.D. (2002), Hoang Le (2003)
o Worked with and supervised the following research associates, cerebrovascular research, University of Chicago: Akihiko Hino, M.D. (1993-1995), Chul-Jin Kim, M.D., Ph.D. (1993-1995), Linda Marton, Ph.D. (1994-2000), Xiaoyu Wang, Ph.D. (1994-1996), Mohamad Bassiouny, M.D. (1994-1996), Yong Yuan Guan, M.D., Ph.D. (1997), Taro Komuro, M.D., Ph.D. (1997-2000), Marcus Stoodley, M.D., Ph.D. (1997-1998), Shigeki Ono, M.D. (1998-2000), Zhen-Du Zhang, M.D., Ph.D. (1998-2001, 2003-), Mina Foroohar, M.D. (1998-1999), Mark Borsody, M.D., Ph.D. (1999-2000), Tetsuro Sayama, M.D., Ph.D. (1999-2001), Yasuo Aihara, M.D., Ph.D. (2000-), Reza Yassari, M.D. (Ph.D. candidate, Committee on Pathology, 2000-), Babak Jahromi, M.D. (Ph.D. candidate, Committee on Neurobiology, Pharmacology and Physiology, 2000-)
Awards to Students:
o Jürgen Lüders - Franklin McLean Award for the most meritorious research by a non-Ph.D. student during medical school, "Intracisternal injection of replication-defective adenovirus containing nitric oxide synthase gene increases cerebral blood flow in rats", May, 1998
o Jürgen Lüders, Calvin Fentress Research Fellowship Award ($1000) for "Adenoviral Mediated Endothelial Nitric Oxide Synthase Gene Transfer Increases Cerebral Blood Flow in Rats", presented at the Senior Scientific Session, Pritzker School of Medicine, May, 1998
o Farbod Asgarzadie-Gadim - Calvin Fentress Research Fellowship Award ($1000) for "Gene Therapy for Obliteration of Arteriovenous Fistulas in Rats", August, 1998
o George Weyer, 1st prize, Howard Hughes Undergraduate Summer Research Seminar Day, "Role of Inwardly-Rectifying Potassium Channels in Cerebral Vasospasm", $500, August, 2003
Presentations at Meetings
1. Skov KA, Macdonald RL, Chaplin DJ, Farrell NP: Toxic and radiosensitizing properties of Pd-misonidazole. Presented at Radiation Research Society Conference, August, 1983, Atlanta, Georgia, USA
2. Macdonald RL, Muller PJ, Tucker WS, Hudson AR: Petrous meningiomas: A review of 17 cases. Presented at the 23rd Canadian Congress of Neurological Sciences, June 15-18, 1988, Quebec City, Quebec, Canada
3. Macdonald RL, Schwartz ML, Sharkey PW, Nelson WR: Diagnosis of cervical spine injuries in motor vehicle accident victims - how many x-rays are enough? Poster at the Annual Meeting of the Trauma Association of Canada, September 22-25, 1989, Edmonton, Alberta
4. Macdonald RL, Weir BKA, Saito K, Kanamaru K, Findlay JM, Grace MG: Cerebral vasospasm in primates caused by intrathecal injections of oxyhemoglobin and bilirubin. Presented at the International Conference on Cerebral Vasospasm, May 15-18, 1990, Tokyo, Japan
5. Macdonald RL, Weir BKA, Saito K, Kanamaru K, Findlay JM, Grace MG: Intrathecal injections of oxyhemoglobin and bilirubin cause cerebral vasospasm in primates. Presented at the 25th meeting of the Canadian Congress of Neurological Sciences, June 27-30, 1990, Banff, Alberta, Canada
6. Macdonald RL, Weir BKA, Acheson A: Changes in cytoskeletal and extracellular matrix proteins after subarachnoid hemorrhage in monkeys. Poster at Alberta Heritage Foundation for Medical Research 10th Annual Heritage Days, November 19-20, 1990, Edmonton, Alberta, Canada
7. Macdonald RL, Weir BKA, Runzer TD, Grace MG, Findlay JM: Oxyhemoglobin and cerebral vasospasm in monkeys. Poster at Alberta Heritage Foundation for Medical Research 10th Annual Heritage Days, November 19-20, 1990, Edmonton, Alberta, Canada
8. Macdonald RL, Weir BKA, Chen M: Scanning electron microscopy of normal and vasospastic monkey cerebrovascular smooth muscle cells. Presented at the 16th International Joint Conference on Stroke and Cerebral Circulation, February 21-23, 1991, San Francisco, California, USA
9. Runzer TD, Weir BKA, Macdonald RL: Lipid peroxidation and cerebral vasospasm. Presented at the 16th International Joint Conference on Stroke and Cerebral Circulation, February 21-23, 1991, San Francisco, California, USA
10. Findlay JM, Macdonald RL, Weir BKA, Grace MG: Effect of operation on established cerebral vasospasm. Presented at the 16th International Joint Conference on Stroke and Cerebral Circulation, February 21-23, 1991, San Francisco, California, USA
11. Macdonald RL, Weir BKA, Grace MGA: Changes in cytoskeletal and extracellular matrix proteins after subarachnoid hemorrhage in monkeys. Poster at the 59th Annual Meeting of American Association of Neurological Surgeons, April 20-25, 1991, New Orleans, Louisiana, USA
12. Macdonald RL, Weir BKA, Runzer TD, Grace MG, Findlay JM: Oxyhemoglobin and cerebral vasospasm in monkeys. Presented at the 59th Annual Meeting of American Association of Neurological Surgeons, April 20-25, 1991, New Orleans, Louisiana, USA
13. Findlay JM, Macdonald RL, Weir B, Grace M: Effect of surgical manipulation on primate cerebral arteries in established vasospasm. Poster at the 59th Annual Meeting of American Association of Neurological Surgeons, April 20-25, 1991, New Orleans, Louisiana, USA
14. Macdonald RL: Mechanism of cerebral vasospasm following subarachnoid hemorrhage in monkeys. Presented at the 26th Meeting of the Canadian Congress of Neurological Sciences, June 18-22, 1991, Halifax, Nova Scotia, Canada
15. Takanashi Y, Weir BKA, Vollrath B, Kasuya H, Macdonald RL: Intracellular free calcium concentration and contractile protein change in cultured vascular smooth muscle cells following prolonged exposure to oxyhemoglobin. Presented at the 26th Meeting of the Canadian Congress of Neurological Sciences, June 18-22, 1991, Halifax, Nova Scotia, Canada
16. Macdonald RL: Hemoglobin causes cerebral vasospasm following subarachnoid hemorrhage. Presented at Canadian Stroke Society Luncheon Symposium at the 26th Meeting of the Canadian Congress of Neurological Sciences, June 18-22, 1991, Halifax, Nova Scotia, Canada
17. Macdonald RL, Weir BKA, Grace MG, Chen M, Young JD, Martin TP: Mechanism of arterial narrowing following subarachnoid hemorrhage in monkeys. Poster at the 41st annual meeting of the Congress of Neurological Surgeons, October 26-31, 1991, Orlando, Florida, USA
18. Macdonald RL, Weir BKA, Runzer TD, Grace MG, Poznansky MJ: Effect of intrathecal superoxide dismutase and catalase on oxyhemoglobin-induced vasospasm in monkeys. Presented at the 60th Annual Meeting of American Association of Neurological Surgeons, April 11-16, 1991, San Francisco, USA
19. Weir BKA, Macdonald RL: New evidence pointing to oxyhemoglobin as the cause of vasospasm. Presented at New Trends in Management of Cerebrovascular Malformations, Verona, Italy, June 8-12, 1992
20. Macdonald RL, Wallace MC: Role of angiography following aneurysm surgery. Presented at the 26th Annual Meeting of the Canadian Congress of Neurological Sciences, June 25-28, 1992, Winnipeg, Manitoba, Canada
21. Macdonald RL, Wallace MC, Kestle JRW: Prediction of unexpected findings on angiography following aneurysm surgery. Poster at the 61st Annual Meeting of American Association of Neurological Surgeons, April 24-29, 1993, Boston, USA
22. Macdonald RL, Tator CH, Wright T, Wallace MC, Bernstein MA, Lozano AM, Fleming JFR: Multilevel anterior cervical decompression and fibula graft fusion for cervical myelopathy. Poster at the 61st Annual Meeting of American Association of Neurological Surgeons, April 24-29, 1993, Boston, USA
23. Macdonald RL, Wallace, MC, Coyne TJ: Effect of surgery on severity of angiographic vasospasm. Presented at the 5th International Conference on Cerebral Vasospasm, May 18-21, 1993, Edmonton, Canada
24. Coyne TJ, Macdonald RL, Wallace MC: Angiographic vasospasm in the nineties - A continuing phenomenon. Presented at the 5th International Conference on Cerebral Vasospasm, May 18-21, 1993, Edmonton, Canada
25. Coyne TJ, Montanera WJ, Wallace MC, Macdonald RL: Angioplasty for cerebral vasospasm - The Toronto Hospital experience. Presented at the 5th International Conference on Cerebral Vasospasm, May 18-21, 1993, Edmonton, Canada
26. Macdonald RL, Wallace MC, Coyne TJ: Effect of surgery on severity of vasospasm. Presented at the 28th Annual Meeting of the Canadian Association of Neurological Sciences, June 16-19, 1993, Toronto, Canada
27. Macdonald RL: Colloid cysts in children. Poster at the 28th Annual Meeting of the Canadian Association of Neurological Sciences, June 16-19, 1993, Toronto, Canada
28. Humphreys RP, Macdonald RL, Rutka JT, Kestle JRW: The III ventricular colloid cyst in children. Presented at the 21st Annual Meeting of the International Society for Pediatric Neurosurgery, October 24-28, 1993, Phoenix, Arizona
29. Macdonald RL, Montanera WJ, Wallace MC, Han H: Effect of transluminal angioplasty on vasospastic rabbit carotid arteries. Poster at the 19th International Joint Conference on Stroke and Cerebral Circulation, February 17-19, 1994, San Diego, California
30. Macdonald RL, Montanera WJ, Wallace MC, Han H, Glen J: Effect of transluminal angioplasty on vasospastic rabbit carotid arteries. Poster at the 62nd Annual Meeting of the American Association of Neurological Surgeons, April 9-14, 1994, San Diego, California
31. Macdonald RL, Montanera W, Wallace MC, Zhang J: Pharmacological effects of transluminal angioplasty on vasospastic rabbit carotid arteries. Poster at the 44th Annual Meeting of the Congress of Neurological Surgeons, October 1-6, 1994, Chicago, Illinois
32. Alexander TD, Macdonald RL, Weir B: Utility of Intraoperative digital subtraction angiography in cerebral aneurysm surgery. Poster at the 44th Annual Meeting of the Congress of Neurological Surgeons, October 1-6, 1994, Chicago, Illinois
33. Macdonald RL, Zhang J, Kane J: Effects of an intracellular calcium chelator on smooth muscle contraction in vitro. Poster at the 20th International Joint Conference on Stroke and the Cerebral Circulation, February 9-11, 1995, Charleston, South Carolina
34. Macdonald RL, Kowalczuk A, Johns L: Small emboli can cause lacunes in primate brain. Poster at the 20th International Joint Conference on Stroke and the Cerebral Circulation, February 9-11, 1995, Charleston, South Carolina
35. Macdonald RL, Marton LS, Johns L: Time course of hydroxyl free radical production after subarachnoid hemorrhage in dogs. Poster at the 63rd Annual Meeting of the American Association of Neurological Surgeons, April 24-27, 1995, Orlando, Florida
36. Macdonald RL, Zhang H, Sima B: Time course of pharmacological characteristics of vasospasm after subarachnoid hemorrhage in dogs. Poster at the 63rd Annual Meeting of the American Association of Neurological Surgeons, April 24-27, 1995, Orlando, Florida
37. Macdonald RL, Johns L: Effect of intraarterial papaverine on vasospasm following subarachnoid hemorrhage in dogs. Poster at the 63rd Annual Meeting of the American Association of Neurological Surgeons, April 24-27, 1995, Orlando, Florida
38. Hino A, Tokuyama Y, Takeda J, Macdonald RL, Weir B: Expression of endothelin and endothelin receptor mRNA after subarachnoid hemorrhage in monkeys. Poster at the 63rd Annual Meeting of the American Association of Neurological Surgeons, April 24-27, 1995, Orlando, Florida
39. Hino A, Weir B, Macdonald RL, Thisted R, Johns L: Prospective, randomized, double-blind trial of BQ-123 and bosentan for prevention of vasospasm following subarachnoid hemorrhage in monkeys. Poster at the 63rd Annual Meeting of the American Association of Neurological Surgeons, April 24-27, 1995, Orlando, Florida
40. Hino A, Macdonald RL, Bell G, Johns L, Kim CJ, Kobayashi M, Takeda J, Thisted R, Tokuyama Y, Weir B, Yano M: Role of endothelins and endothelin receptors in vasospasm following subarachnoid hemorrhage in monkeys. Presented at the 4th International Workshop on Cerebrovascular Surgery, Chicago, June 11-14, 1995
41. Macdonald RL, Zhang H, Johns L, Sima B: Multiple phases of vasospasm following subarachnoid hemorrhage in dogs. Poster at the 4th International Workshop on Cerebrovascular Surgery, Chicago, June 11-14, 1995
42. Alexander TD, Macdonald RL, Weir B: Intraoperative angiography following removal of arteriovenous malformations. Poster at the 4th International Workshop on Cerebrovascular Surgery, Chicago, June 11-14, 1995
43. Alexander TD, Macdonald RL, Weir B: Value of intraoperative angiography for decreasing complications of aneurysm surgery. Presented at the 4th International Workshop on Cerebrovascular Surgery, Chicago, June 11-14, 1995
44. Chen Y, Hoffman KR, Macdonald RL, Hackworth CA, Doi K: Comparison of techniques for measurement of vessel sizes in angiograms. Presented at the 37th Annual Meeting of the American Association of Physicists in Medicine, Boston, July 23-27, 1995
45. Macdonald RL, Zhang H, Johns L, Sima B: Multiple phases of vasospasm following subarachnoid hemorrhage in dogs. Presented at the 45th Annual Meeting of the Congress of Neurological Surgeons, San Francisco, October 14-19, 1995
46. Ryan MJ, Erickson RK, Levin DN, Pelizzari CA, Macdonald RL, Dohrmann GJ: Frameless stereotaxy with real-time tracking of patient head movement and retrospective patient-image registration. Presented at the 2nd Annual International Symposium on Medical Robotics and Computer Assisted Surgery, Baltimore, November 4-7, 1995
47. Hino A, Tokuyama Y, Weir BK, Takeda J, Bell GI, Macdonald RL: Expression of nitric oxide synthase and soluble guanylate cyclase mRNA in cerebral arteries after subarachnoid hemorrhage in monkeys. Presented at the 1st Annual meeting of the Joint Section on Cerebrovascular Surgery, San Antonio, January 23-25, 1996
48. Kowalczuk A, Macdonald RL, Amidei C, Hekmatpanah J, Erickson RK, Brown F, Weir BK: Quantitative postoperative imaging study of the effect of surgical resection of malignant astrocytomas on survival. Poster presented at the 64th Annual Meeting of the American Association of Neurological Surgeons, April 27-May 2, 1996, Minneapolis, Minnesota
49. Sima B, Macdonald RL, Zhang J, Weir BK, Marton LS: Effect of P2-purinoceptor antagonists on hemolysate- and ATP-induced contractions of dog basilar artery in vitro. Poster presented at the 64th Annual Meeting of the American Association of Neurological Surgeons, April 27-May 2, 1996, Minneapolis, Minnesota
50. Macdonald RL, Zhang J, Weir BK, Johns L, Sepehri S: ATP causes chronic vasospasm of the rat femoral artery. Poster presented at the 64th Annual Meeting of the American Association of Neurological Surgeons, April 27-May 2, 1996, Minneapolis, Minnesota
51. Kim CJ, Bassiouny M, Weir BK, Macdonald RL, Johns LM: Prevention of vasospasm in monkeys by combined treatment with an endothelin antagonist and tissue plasminogen activator. Poster at the 46th Annual Meeting of the Congress of Neurological Surgeons, September 28-October 3, 1996, Montreal, Canada
52. Macdonald RL, Weir BK: Combined hematoma and AVM removal as an alternative to staged removal in patients with ruptured AVM. Poster at the 46th Annual Meeting of the Congress of Neurological Surgeons, September 28-October 3, 1996, Montreal, Canada
53. Macdonald RL, Johns L: Prevention of vasospasm after SAH in dogs by continuous intravenous infusion of PD156707. Poster at the 2nd Annual Meeting of the Section on Cerebrovascular Surgery of the AANS/CNS, February 4-6, 1997, Anaheim, California
54. Wang X, Macdonald RL, Bell G: Effect of hemoglobin on immediate early gene expression in cultured rat aortic smooth muscle cells. Poster at the 2nd Annual Meeting of the Section on Cerebrovascular Surgery of the AANS/CNS, February 4-6, 1997, Anaheim, California
55. Zhang H, Weir BKA, Marton KS, Lee KS, Macdonald RL: P2 purinoceptors in cerebral endothelium and their roles in cerebral vasospasm. Poster at the 22nd International Joint Conference on Stroke and Cerebral Circulation, February 6-8, 1997, Anaheim, California
56. Macdonald RL, Johns L: Prevention of vasospasm after subarachnoid hemorrhage in dogs by continuous intravenous infusion of PD156707. Presented at the 5th International Workshop on Cerebrovascular Surgery, March 3-5, 1997, Fukuoka, Japan
57. Mojtahedi S, Macdonald RL, Johns L: Randomized, prospective comparison of GD coils and cellulose acetate polymer for treatment of aneurysms in dogs. Presented at the 5th International Workshop on Cerebrovascular Surgery, March 3-5, 1997, Fukuoka, Japan
58. Mojtahedi S, Macdonald RL, Johns: Randomized, prospective comparison of GD coils and cellulose acetate polymer for treatment of aneurysms in dogs. Poster at the 65th Annual Meeting of the American Association of Neurological Surgeons, April 12-17, 1997, Denver, Colorado
59. Wang X, Macdonald RL, Bell G, Marton L: Effects of hemoglobin and hemolysate on heme oxygenase and ferritin in smooth muscle cells. Presented at the 6th International Conference on Cerebral Vasospasm, May 11-15, 1997, Sydney, Australia
60. Macdonald RL, Zhang J, Marton L, Johns L, Sajdak M, Weir B: Adenosine triphosphate as a possible cause of vasospasm in monkeys. Presented at the 6th International Conference on Cerebral Vasospasm, May 11-15, 1997, Sydney, Australia
61. Bassiouny M, Sajdak M, Macdonald RL, Weir B, Johns L: U74389G prevents vasospasm after subarachnoid hemorrhage in dogs by inhibition of lipid peroxidation. Presented at the 6th International Conference on Cerebral Vasospasm, May 11-15, 1997, Sydney, Australia
62. Macdonald RL, Zhang J, Hino A: Characterization of endothelin receptors in monkey basilar artery. Presented at the 6th International Conference on Cerebral Vasospasm, May 11-15, 1997, Sydney, Australia
63. Macdonald RL, Weir B, Zhang J, Marton L, Johns L, Sajdak M: Adenosine triphosphate as a possible cause of vasospasm in monkeys. Presented at the 59th Annual meeting of the American Academy of Neurological Surgery. September 10-13, 1997, Banff, Alberta, Canada
64. Macdonald RL, Marton LS, Kowalczuk A, Wang X, Windmeyer E: Effects of hemoglobins on heme oxygenase-1 and viability of cultured smooth muscle cells. Presented at the 83rd Clinical Congress of the American College of Surgeons, October 12-17, 1997, Chicago, Illinois
65. Macdonald RL, Bassiouny M, Johns L, Sajdak M, Marton LS, Weir BK, Hall ED, Andrus PK: U74389G prevents vasospasm after subarachnoid hemorrhage in dogs. Poster at the 1st Joint Meeting of the American Society of Interventional and Therapeutic Neuroradiology and the Section on Cerebrovascular Surgery of the American Association of Neurological Surgeons and Congress of Neurological Surgeons, February 1-4, 1998, Lake Buena Vista, Florida
66. Guan YY, Weir B, Marton L, Macdonald R, Zhang J: Comparison of effects of aged erythrocyte lysate on [Ca2+]i in rat basilar smooth muscle cells. Presented at Experimental Biology 1998 (FASEB meeting), April 18-22, 1998, San Francisco, California
67. Macdonald RL, Weir B, Zhang J, Marton LS, Sajdak M, Johns LM: Adenosine triphosphate and hemoglobin cause vasospasm in monkeys. Poster at the 66th Annual Meeting of the American Association of Neurological Surgeons, April 25-30, 1998, Philadelphia, Pennsylvania
68. Macdonald RL, Amidei C, Lin G: Safety of perioperative subcutaneous heparin for prophylaxis of venous thromboembolism in patients undergoing intracranial surgery. Poster at the 66th Annual Meeting of the American Association of Neurological Surgeons, April 25-30, 1998, Philadelphia, Pennsylvania
69. Nicholas NK, Sweeney PJ, Masters G, Mundt AJ, Krauss S, Macdonald RL, Szeto L, Vokes EE: Phase 1 trial of vinorelbine with concurrent radiotherapy in malignant glioma: diminished toxicities at conventional doses. Presented at the 34th Annual Meeting of the American Society for Clinical Oncology, May 16-19, 1998, Los Angeles, California
70. Macdonald RL, Ghadge G, Weihl C, Stoodley M, Johns L, Lin G, Kowalczuk A, Roos R: Effect of adenoviral nitric oxide synthase gene transfer on vasospasm after subarachnoid hemorrhage. Presented at the 1st Annual Meeting of the American Society of Gene Therapy, May 28-31, 1998, Seattle, Washington
71. Macdonald RL, Ghadge G, Weihl C, Stoodley M, Johns L, Lin G, Kowalczuk A, Roos R: Effect of adenoviral nitric oxide synthase gene transfer on vasospasm after subarachnoid hemorrhage. Presented at the 1998 Annual Meeting of the Research Society of Neurological Surgeons, June 17-20, 1998, Oklahoma City, Oklahoma
72. Jani AB, Pelizzari CA, Chen GTY, Roeske JC, Hamilton RJ, Macdonald RL, Bova F, Sweeney P: Volume rendering image segmentation for cerebral arteriovenous malformations. Presented at the International Workshop on Computer-Aided Diagnosis, September, 1988, Chicago, Illinois
73. Macdonald RL, Ghadge G, Weihl C, Stoodley M, Johns LS, Lin G, Kowalczuk A, Roos R: Effect of adenoviral nitric oxide synthase gene transfer on vasospasm after subarachnoid hemorrhage. Presented at the Congress of Neurological Surgeons Post Satellite Meeting, Blaine, Washington, October 8-10, 1998
74. Jani AB, Pelizzari CA, Chen GTY, Roeske JC, Hamilton RJ, Macdonald RL, Bova F, Sweeney P: Segmentation of cerebral AVM's using volume rendering. Presented at the India Medical Association Academic Forum, October, 1998, Chicago, Illinois
75. Jani AB, Pelizzari CA, Chen GTY, Roeske JC, Hamilton RJ, Macdonald RL, Bova F, Sweeney P: Volume rendering segmentation algorithm (VRSA) for systematic comparison of visualization techniques for cerebral arteriovenous malformations. Poster at the 40th Annual Meeting of the American Society for Therapeutic Radiology and Oncology, October 25-29, 1998, Phoenix, Arizona
76. Macdonald RL, Weir BKA, Marton LS, Windmeyer E, Johns L, Kowalczuk A, Lin G: Heme oxygenase-1 and ferritin proteins are increased in cerebral arteries after subarachnoid hemorrhage in monkeys. Presented at the 84th Annual Clinical Congress of the American College of Surgeons, Orlando, Florida, October 26-29, 1998
77. Stoodley M, Foroohar M, Macdonald RL, Weir B: Multimedia computer database for neurovascular surgery. Presented at 75 Years of Neurosurgery in Canada, 1923-1998, Toronto, Canada, October 29-31, 1998
78. Macdonald RL, Ghadge G, Weihl C, Stoodley M, Johns LS, Lin G, Kowalczuk A, Roos R: Effect of adenoviral-mediated nitric oxide synthase gene transfer on vasospasm after experimental subarachnoid hemorrhage. Presented at the 60th Annual Meeting of the American Academy of Neurological Surgeons, Santa Barbara, California, November 4-8, 1998
79. Stoodley MA, Macdonald RL, Weir BK, Marton LS, Johns L, Sajdak M, Zhang J, Kowalczuk A: Prolonged cerebral vasospasm depends on the presence of subarachnoid blood for a minimum of three days. Poster at the 2nd Joint Meeting of the American Society of Interventional and Therapeutic Neuroradiology and the Section on Cerebrovascular Surgery of the American Association of Neurological Surgeons and Congress of Neurological Surgeons, January 31-February 3, 1999, Nashville, Tennessee
80. Munshi I, Frim D, Stine-Reyes R, Weir B, Macdonald RL, Hekmatpanah J, Brown F: Effects of posterior fossa decompression with and without duroplasty on Chiari malformation associated syringomyelia. Poster at the 15th Annual Meeting of the Section on Disorders of the Spine and Peripheral Nerves of the AANS/CNS, February 10-13, 1999, Lake Buena Vista, Florida
81. Luders J, Lin G, Weihl C, Ghadge G, Stoodley M, Roos R, Macdonald RL: Intrathecal adenoviral gene transfer of nitric oxide synthase increases cerebral blood flow in rats. Poster at the 67th Annual Meeting of the American Association of Neurological Surgeons, April 24-29, 1999, New Orleans, Louisiana
82. Macdonald RL, Weir B, Ghadge G, Weihl C, Stoodley M, Johns L, Lin G, Kowalczuk A, Roos R: Effect of adenoviral-mediated nitric oxide synthase gene transfer on vasospasm after experimental subarachnoid hemorrhage. Poster at the 67th Annual Meeting of the American Association of Neurological Surgeons, April 24-29, 1999, New Orleans, Louisiana
83. Munshi I, Macdonald RL, Weir B: Limitations of intraoperative angiography in management of brain arteriovenous malformations. Poster at the 67th Annual Meeting of the American Association of Neurological Surgeons, April 24-29, 1999, New Orleans, Louisiana
84. Stoodley MA, Weir BK, Foroohar M, Macdonald RL: Multimedia neurosurgery database. Presented at the 3rd Congress of the International Society for Neurosurgical Technology and Instrument Invention, April 29-May 2, 1999, Las Vegas, Nevada
85. Luders J, Lin G, Weihl C, Ghadge G, Stoodley M, Roos R, Macdonald RL: Intrathecal adenoviral gene transfer of nitric oxide synthase increases cerebral blood flow in rats. Poster at the Brain Research Foundation Neuroscience Day, April 30, 1999, Chicago, Illinois
86. Macdonald RL, Weir B, Ghadge G, Weihl C, Stoodley M, Johns L, Lin G, Kowalczuk A, Roos R: Effect of adenoviral-mediated nitric oxide synthase gene transfer on vasospasm after experimental subarachnoid hemorrhage. Poster at the Brain Research Foundation Neuroscience Day, April 30, 1999, Chicago, Illinois
87. Foroohar M, Macdonald RL, Stoodley M, Roth S, Weir B: Influence of intraoperative variables on outcome after aneurysm surgery. Poster at the Brain Research Foundation Neuroscience Day, April 30, 1999, Chicago, Illinois
88. Macdonald RL, Weir B, Marton LS, Kowalczuk A, Stoodley M: Studies on the etiology of cerebral vasospasm. Presented at the 6th Charles Huggins Annual Research Conference, May 22, 1999, Chicago, Illinois
89. Foroohar M, Macdonald RL, Stoodley M, Roth S, Weir B: Influence of intraoperative variables on outcome after aneurysm surgery. Presented at the 6th Charles Huggins Annual Research Conference, May 22, 1999, Chicago, Illinois
90. Munshi I, Frim D, Stine-Reyes R, Weir B, Macdonald RL, Hekmatpanah J, Brown F: Effects of posterior fossa decompression with and without duroplasty on Chiari malformation-associated syringomyelia. Poster at the 6th Charles Huggins Annual Research Conference, May 22, 1999, Chicago, Illinois
91. Stoodley MA, Weir BK, Foroohar M, Macdonald RL: Multimedia neurosurgery database. Presented at the 34th Canadian Congress of Neurological Sciences Annual Meeting, June 15-19, 1999, Edmonton, Canada
92. Stoodley MA, Weir B, Foroohar, M, Macdonald RL: Multimedia database for neurovascular surgery. Poster at the 49th Annual Meeting of the Congress of Neurological Surgeons, October 30-November 4, 1999, Boston, MA
93. Foroohar M, Macdonald RL, Roth S, Stoodley M, Weir B: Influence of intraoperative variables on outcome after aneurysm surgery. Poster at the 49th Annual Meeting of the Congress of Neurological Surgeons, October 30-November 4, 1999, Boston, MA
94. Foroohar M, Macdonald RL, Roth S, Stoodley M, Weir B: Influence of intraoperative variables on outcome after aneurysm surgery. Presented at the Joint Meeting of the AANS/CNS Section on Cerebrovascular Surgery and the American Society of Interventional and Therapeutic Neuroradiology, February 6-9, 2000, New Orleans, Louisiana
95. Macdonald RL, Ono S, Zhang ZD, Marton L, YaminiB, Windmeyer E, Johns L, Kowalczuk A, Lin G: Induction of heme oxygenase and ferritin in cerebral arteries after subarachnoid hemorrhage in monkeys. Presented at the Joint Meeting of the AANS/CNS Section on Cerebrovascular Surgery and the American Society of Interventional and Therapeutic Neuroradiology, February 6-9, 2000, New Orleans, Louisiana
96. Macdonald RL, Weir B, Marton LS, Zhang ZD, Sajdak M, Johns LM, Kowalczuk A, Borsody M: Role of adenosine triphosphate in vasospasm: human investigations. Poster at the Joint Meeting of the AANS/CNS Section on Cerebrovascular Surgery and the American Society of Interventional and Therapeutic Neuroradiology, February 6-9, 2000, New Orleans, Louisiana
97. Zhang ZD, Macdonald RL, Ono S, Marton L, Weir B: Gene differentially expressed during cerebral vasospasm. Presented at the 6th Internet World Congress for Biomedical Science, February 14-25, 2000
98. Macdonald RL: The role of adenosine triphosphate in vasospasm after subarachnoid hemorrhage: human investigations. Presented at the 6th Internet World Congress for Biomedical Science, February 14-25, 2000
99. Macdonald RL, Weir B, Marton LS, Zhang ZD, Sajdak M, Johns LM, Kowalczuk A, Borsody M: The role of adenosine triphosphate in vasospasm after subarachnoid hemorrhage: human investigations. Poster at the 68th Annual Meeting of the American Association of Neurological Surgeons, April 8-13, 2000, San Francisco, California
100. Foroohar M, Macdonald RL, Roth S, Stoodley M, Weir B: Intraoperative variables and early outcome after aneurysm surgery. Poster at the 68th Annual Meeting of the American Association of Neurological Surgeons, April 8-13, 2000, San Francisco, California
101. Munshi I, Macdonald RL, Weir B: Intraoperative angiography of brain arteriovenous malformations. Presented at the 68th Annual Meeting of the American Association of Neurological Surgeons, April 8-13, 2000, San Francisco, California
102. Macdonald RL: Discussant on: Lang EW, Diehl RR, Mehdorn HM: Systemic cerebral autoregulation testing after severe SAH. 68th Annual Meeting of the American Association of Neurological Surgeons, April 8-13, 2000, San Francisco, California
103. Stoodley MA, Macdonald RL, Weir BKA, Marton LS, Johns LM, Sajdak M, Zhang J, Kowalczuk A: Subarachnoid haemorrhage causes an adaptive response in cerebral arteries. Presented at the Royal Australasian College of Surgeons Annual Scientific Congress, May, 2000, Melbourne, Australia
104. Stoodley MA, Weir BK, Foroohar M, Macdonald RL: Multimedia database for neurosurgery. Presented at the Royal Australasian College of Surgeons Annual Scientific Congress, May, 2000, Melbourne, Australia
105. Macdonald RL, Ono S, Marton LS, Ahmed I, Stoodley M, Komuro T, Zhang ZD, Yamini B, Weir B: Studies on the molecular weight of the interaction required for experimental vasospasm. Presented at the 7th International Conference on Cerebral Vasospasm, June 18-21, 2000, Interlaken, Switzerland
106. Komuro T, Borsody MK, Ono S, Marton LS, Macdonald RL: Carbon-monoxide-induced relaxation of dog basilar artery via cyclic-GMP and K+ channel-dependent pathway. Poster at the 7th International Conference on Cerebral Vasospasm, June 18-21, 2000, Interlaken, Switzerland
107. Zhang ZD, Macdonald RL, Ono S, Marton LS, Weir B: Genes differentially expressed during experimental cerebral vasospasm. Presented at the 7th International Conference on Cerebral Vasospasm, June 18-21, 2000, Interlaken, Switzerland
108. Ono S, Komuro T, Choi A, Macdonald RL: Adenovirus-mediated heme oxygenase-1 gene transfection prevents hemoglobin-induced contraction of rat basilar artery. Presented at the 7th International Conference on Cerebral Vasospasm, June 18-21, 2000, Interlaken, Switzerland
109. Jahromi B, Komuro T, Macdonald RL, Marton LS, Weir BK: Phosphatidylcholine peroxidized by hemoglobin increases intracellular calcium in dog basilar artery smooth muscle cells. Presented at the 7th International Conference on Cerebral Vasospasm, June 18-21, 2000, Interlaken, Switzerland
110. Zhang ZD, Yamini B, Macdonald RL, Ono S, Marton LS, Komuro T, Weir B: Experimental vasospasm resolves secondary to loss of blood clot and adaptive response in cerebral arteries. Presented at the 7th International Conference on Cerebral Vasospasm, June 18-21, 2000, Interlaken, Switzerland
111. Macdonald RL, Zhang ZD, Yamini B, Ono S, Marton LS, Komuro T, Weir B: Changes in gene expression do not mediate resolution of vasospasm after subarachnoid hemorrhage in primates. Presented at the 50th Annual Meeting of the Congress of Neurological Surgeons, September 23-28, 2000, San Antonio, Texas
112. Macdonald RL, Amidei C, Baron J, Weir B, Hekmatpanah J, Brown F, Erickson R, Frim D, Gupta N: Randomized, blinded, prospective comparison of dalteparin and low dose subcutaneous heparin for prevention of venous thromboembolic complications in patients undergoing craniotomy. Presented at the 50th Annual Meeting of the Congress of Neurological Surgeons, September 23-28, 2000, San Antonio, Texas
113. Borsody MK, DeGiovanni GM, Marton LS, Macdonald RL, Weir B: Thrombin reduces cerebral arterial contractions caused by cerebrospinal fluid from patients with subarachnoid hemorrhage patients. Presented at the 86th Clinical Congress of the American College of Surgeons, October 22-27, 2000, Chicago, Illinois
114. Ono S, Komuro T, Weir B, Macdonald RL: Heme oxygenase-1 gene therapy for prevention of vasospasm in rats. Presented at the1st American-Japanese Meeting for Surgical and Endovascular Treatment of Cerebrovascular Disorders, February 9-12, 2001, Waikoloa, Hawaii
115. Macdonald RL, Zhang ZD, Marton LS, Ono S, Komuro T, Weir B: Genes differentially expressed in cerebral arteries after subarachnoid hemorrhage in monkeys. Poster at the1st American-Japanese Meeting for Surgical and Endovascular Treatment of Cerebrovascular Disorders, February 9-12, 2001, Waikoloa, Hawaii
116. Macdonald RL, Ono S, Marton LS, Ahmed I, Stoodley M, Komuro T, Zhang ZD, Yamini B, Weir B: Studies on the molecular weight of the interaction required for development of experimental vasospasm. Poster at the 1st American-Japanese Meeting for Surgical and Endovascular Treatment of Cerebrovascular Disorders, February 9-12, 2001, Waikoloa, Hawaii
117. Yamini B, Ono S, Zhang ZD, Marton LS, Johns LS, Weir B, Macdonald RL: Time course of changes in nitric oxide synthases following subarachnoid hemorrhage in primates. Poster at the1st American-Japanese Meeting for Surgical and Endovascular Treatment of Cerebrovascular Disorders, February 9-12, 2001, Waikoloa, Hawaii
118. Ono S, Macdonald RL: Heme oxygenase gene therapy for prevention of vasospasm in rats. Presented at the 26th International Stroke Conference, February 14-16, 2001, Fort Lauderdale, Florida
119. Macdonald RL, Zhang ZD, Weir B: Why experimental vasospasm resolves. Poster at the 26th International Stroke Conference, February 14-16, 2001, Fort Lauderdale, Florida
120. Macdonald RL, Zhang ZD, Johns L, Ono S, Komuro T, Weir BK: Persistence of vasospasm is due to changes in gene expression in cerebral arteries. Poster at the 70th Annual Meeting of the American Association of Neurological Surgeons, April 21-26, 2001, Toronto, Canada
121. Macdonald RL, Ono S, Komuro T: Heme oxygenase-1 gene therapy for prevention of vasospasm in rats. Poster at the 70th Annual Meeting of the American Association of Neurological Surgeons, April 21-26, 2001, Toronto, Canada
122. Macdonald RL, Rosengart A: Metaanalysis of effect of tirilazad on outcome after aneurysmal subarachnoid hemorrhage. Presentation at the 12th World Congress of Neurosurgery, September 17-20, 2001, Sydney, Australia
123. Macdonald RL, Rosengart A: Multvariate analysis of factors predicting vasospasm after aneurysmal subarachnoid hemorrhage. Presentation at the 12th World Congress of Neurosurgery, September 17-20, 2001, Sydney, Australia
124. Macdonald RL, Borsody MK, DeGiovanni GM, Marton LS: Evidence that thrombin in cerebrospinal fluid after subarachnoid hemorrhage reduces vasospasm. Presentation at the 51st Annual Meeting of the Congress of Neurological Surgeons, September 29-October 4, 2001, San Diego, California
125. Curry DJ, Asgarzadie F, Luders J, Macdonald RL: Impact of obesity on neurosurgical patients. Poster at the 51st Annual Meeting of the Congress of Neurological Surgeons, September 29-October 4, 2001, San Diego, California
126. Macdonald RL, and the Participants: Prognostic factors for outcome after aneurysmal subarachnoid hemorrhage in the tirilazad studies. Poster at the 51st Annual Meeting of the Congress of Neurological Surgeons, September 29-October 4, 2001, San Diego, California
127. Rosengart A, Macdonald RL, Weir B: Prognostic factors for outcome and clinical grading of aneurysmal SAH based on metaanalysis of the tirilazad database. Presented at the 5th Joint Annual Meeting of the AANS/CNS Section on Cerebrovascular Surgery and the American Society of Interventional and Therapeutic Neuroradiology, February 3-6, 2002, Dallas, Texas
128. Rosengart A, Macdonald RL, Weir B: Metaanalysis of the effect of tirilazad on outcome and vasospasm after aneurysmal SAH. Presented at the 5th Joint Annual Meeting of the AANS/CNS Section on Cerebrovascular Surgery and the American Society of Interventional and Therapeutic Neuroradiology, February 3-6, 2002, Dallas, Texas
129. Macdonald RL, Zhang ZD, Curry D, Aihara Y, Jahromi B: Sodium nitroprusside does not prevent experimental vasospasm. Presented at the 5th Joint Annual Meeting of the AANS/CNS Section on Cerebrovascular Surgery and the American Society of Interventional and Therapeutic Neuroradiology, February 3-6, 2002, Dallas, Texas
130. Rosengart A, Macdonald RL, Weir B: Prognostic factors for outcome and clinical grading of aneurysmal SAH based on metaanalysis of the tirilazad database. Poster at the 70th Annual Meeting of the American Association of Neurological Surgeons, April 6-11, 2002, Chicago, Illinois
131. Rosengart A, Macdonald RL, Weir B: Metaanalysis of the effect of tirilazad on outcome and vasospasm after aneurysmal SAH. Poster at the 70th Annual Meeting of the American Association of Neurological Surgeons, April 6-11, 2002, Chicago, Illinois
132. Macdonald RL, Zhang ZD, Curry D, Elas M, Aihara Y, Halpern H, Jahromi B, Johns L: Sodium nitroprusside does not prevent experimental vasospasm. Poster at the 70th Annual Meeting of the American Association of Neurological Surgeons, April 6-11, 2002, Chicago, Illinois
133. Aihara Y, Jahromi BS, Yassari R, Sayama T, Macdonald RL: Effect of a nitric oxide donor on experimental vasospasm. Presented at the 52nd Annual Meeting of the Congress of Neurological Surgeons, September 21-26, 2002, Philadelphia, Pennsylvania
134. Yassari R, Sayama T, Jahromi BS, Aihara Y, Macdonald RL: Arteriovenous fistula in rats: angiographic, hemodynamic and histological features mimic human AVMs. Poster at the 52nd Annual Meeting of the Congress of Neurological Surgeons, September 21-26, 2002, Philadelphia, Pennsylvania
135. Macdonald RL, Aihara Y, Jahromi BS, Yassari R: Effect of a nitric oxide donor on experimental vasospasm in nonhuman primates. Poster at the 28th International Stroke Conference, February 13-15, 2003, Phoenix, Arizona
136. Macdonald RL: Intraoperative angiography via the superficial temporal artery. Presented at the 6th Joint Annual Meeting of the AANS/CNS Section on Cerebrovascular Surgery and the American Society of Interventional and Therapeutic Neuroradiology, February 16-19, 2003, Phoenix, Arizona
137. Yassari R, Sayama T, Jahromi BS, Aihara Y, Macdonald RL: Arteriovenous fistula in rats: angiographic, hemodynamic and histological features mimic human AVMs. Poster at the 6th Joint Annual Meeting of the AANS/CNS Section on Cerebrovascular Surgery and the American Society of Interventional and Therapeutic Neuroradiology, February 16-19, 2003, Phoenix, Arizona
138. Aihara Y, Jahromi BS, Yassari R, Zhang ZD, Macdonald RL: Nitric oxide replenishment does not prevent experimental vasospasm: possible block in distal vasorelaxation pathway. Poster at the 71st Annual Meeting of the American Association of Neurological Surgeons, April 27-May 1, 2003, San Diego, California
139. Jahromi BS, Aihara Y, Weyer G, Agbaje-Williams M, Nikitina E, Yassari R, Macdonald RL: Potassium channel dysfunction in cerebral vasospasm. Poster at the 71st Annual Meeting of the American Association of Neurological Surgeons, April 27-May 1, 2003, San Diego, California
140. Aihara Y, Jahromi BS, Yassari R, Nikitina E, Agbaje-Williams M, Macdonald RL: Molecular profile of vascular ion channels after subarachnoid hemorrhage. Presented at the 8th International Conference on Cerebral Vasospasm, July 9-12, 2003, Chicago, IL
141. Jahromi BS, Aihara Y, Agbaje-Williams M, Nikitina E, Weyer G, Ryan D, Yassari R, Macdonald RL: Potassium channel dysfunction in cerebral vasospasm. Presented at the 8th International Conference on Cerebral Vasospasm, July 9-12, 2003, Chicago, IL
142. Rosen DS, Macdonald RL: A modification of the world federation of neurological surgeons scale for subarachnoid hemorrhage: The prognostic significance of historical, clinical and radiographic parameters in a large patient series. Presented at the 8th International Conference on Cerebral Vasospasm, July 9-12, 2003, Chicago, IL
143. Jahromi BS, Aihara Y, Agbaje-Williams M, Nikitina E, Weyer G, Ryan D, Yassari R, Macdonald RL: Voltage-gated potassium channels are downregulated in experimental cerebral vasospasm. Presented at the 53rd Annual Meeting of the Congress of Neurological Surgeons, October 18-23, 2003, Denver, CO
Citations in Science Citation Index: 1523 (as of 10/02)
Refereed Publications:
1. Macdonald RL, Findlay JM, Tator CH: Microcystic spinal cord degeneration causing posttraumatic myelopathy. Report of 2 cases. J Neurosurg 68:466-471, 1988
2. Macdonald RL, Findlay JM, Tator CH: Sphenoethmoidal sinusitis complicated by cavernous sinus thrombosis and pontocerebellar infarction. Can J Neurol Sci 15:310-313, 1988
3. Macdonald RL, Bernstein M: Emergency lumbar puncture in adults: Is it ever indicated? Can Fam Physician 35:1183-1186, 1989
4. Macdonald RL, Cusimano MD, Deck JHN, Gullane PJ, Dolan EJ: Cerebrospinal fluid fistula secondary to ecchordosis physaliphora. Neurosurgery 26:515-519, 1990
5. Macdonald RL, Schwartz ML, Sharkey PW, Nelson WR: Diagnosis of cervical spine injuries in motor vehicle crash victims - how many x-rays are enough. J Trauma 30:392-397, 1990
6. Kanamaru K, Weir BKA, Findlay JM, Grace M, Macdonald RL: A dosage study of the effect of the 21-aminosteroid U74006F on chronic cerebral vasospasm in a primate model. Neurosurgery 27:29-38, 1990
7. Macdonald RL, Deck JHN: Immunohistochemistry of ecchordosis physaliphora and chordoma. Can J Neurol Sci 17:420-423, 1990
8. Macdonald RL, Muller PJ, Tucker WS, Moulton RJ, Hudson AR: Petrous meningiomas: A review of seventeen cases. Can J Neurol Sci 15:399-403, 1990
9. Macdonald RL, Schwartz ML, Lewis AJ: Neurenteric cyst located dorsal to the cervical spine: case report. Neurosurgery 28:583-588, 1991
10. Klimek EH, Macdonald RL, Deck JHN: Pneumocephalus following treatment of esthesioneuroblastoma. Can J Neurol Sci 18:358-360, 1991
11. Macdonald RL, Weir BKA, Runzer TD, Grace MGA, Findlay JM, Saito K, Cook DA, Mielke BW, Kanamaru K: Etiology of cerebral vasospasm in primates. J Neurosurg 75:415-424, 1991
12. Findlay JM, Macdonald RL, Weir BKA, Grace MGA: Surgical manipulation of primate cerebral arteries in established vasospasm. J Neurosurg 75:425-432, 1991
13. Macdonald RL, Weir BKA, Chen M: Scanning electron microscopy of normal and vasospastic monkey cerebrovascular smooth muscle cells. Neurosurgery 29:544-550, 1991
14. Macdonald RL, Weir BKA, Grace MGA, Martin TP, Doi M, Cook DA: Morphometric analysis of monkey cerebral arteries exposed in vivo to whole blood, oxyhemoglobin, methemoglobin, and bilirubin. Blood Vessels 28:498-510, 1991
15. Macdonald RL, Weir BKA, Young JD, Grace MGA: Cytoskeletal and extracellular matrix proteins in cerebral arteries following subarachnoid hemorrhage in monkeys. J Neurosurg 76:81-90, 1992
16. Macdonald RL, Weir BKA, Runzer TD, Grace MGA, Poznansky M: Effect of intrathecal superoxide dismutase and catalase on oxyhemoglobin-induced vasospasm in monkeys. Neurosurgery 30:529-539, 1992
17. Takanashi Y, Weir BKA, Vollrath B, Kasuya H, Macdonald RL, Cook D: Time course of changes in concentration of intracellular free calcium in cultured cerebrovascular smooth muscle cells exposed to oxyhemoglobin. Neurosurgery 30:346-350, 1992
18. Macdonald RL, Weir BKA, Runzer TD, Grace MGA: Malondialdehyde, glutathione peroxidase, and superoxide dismutase in cerebrospinal fluid during cerebral vasospasm in monkeys. Can J Neurol Sci 19:326-332, 1992
19. Macdonald RL, Weir BKA, Grace MGA, Chen MH, Martin TP, Young JD: Mechanism of cerebral vasospasm following subarachnoid hemorrhage in monkeys. Can J Neurol Sci 19:419-427, 1992
20. Macdonald RL, Wallace MC, Kestle JRW: Role of angiography following aneurysm surgery. J Neurosurg 79:826-832, 1993
21. Macdonald RL, Hoffman HJ, Kestle JRW, Rutka JT, Weinstein G: Needle aspiration of acute subdural hematomas in infancy. Pediatr Neurosurg 20:73-77, 1994
22. Macdonald RL, Humphreys RP, Rutka JT, Kestle JRW: Colloid cysts in children. Ped Neurosurg 20:169-177, 1994
23. Macdonald RL, Wallace MC, Coyne TJ: The effect of surgery on the severity of vasospasm. J Neurosurg 80:433-439, 1994
24. Vollrath BAM, Weir BKA, Macdonald RL, Cook DA: Intracellular mechanisms involved in the responses of cerebrovascular smooth muscle cells to haemoglobin. J Neurosurg 80:261-268, 1994
25. Coyne TJ, Montanera WJ, Macdonald RL, Wallace MC: Percutaneous transluminal angioplasty for cerebral vasospasm after subarachnoid hemorrhage. Can J Surg 37:391-396, 1994
26. Coyne TJ, Macdonald RL, Wallace MC: Angiographic vasospasm in a contemporary series of patients with aneurysmal subarachnoid haemorrhage. J Clin Neurosci 1:106-110, 1994
27. Macdonald RL, Zhang J, Han H: Angioplasty reduces pharmacologically-mediated vasoconstriction in rabbit carotid arteries with and without vasospasm. Stroke 26:1053-1060, 1995
28. Macdonald RL, Wallace MC, Montanera WJ, Glenn J: Pathological effects of angioplasty on vasospastic rabbit carotid arteries. J Neurosurg 83:111-117, 1995
29. Macdonald RL, Kowalczuk A, Johns L: Emboli enter penetrating arteries of monkey brain in relation to their size. Stroke 26:1247-1251, 1995
30. Hino A, Weir B, Macdonald RL, Thisted R, Kim CJ, Johns L: Prospective, randomized, double-blind trial of BQ-123 and bosentan for prevention of vasospasm following subarachnoid hemorrhage in monkeys. J Neurosurg 83:503-509, 1995
31. Macdonald RL, Zhang J, Sima B, Johns L: Papaverine-sensitive vasospasm and arterial contractility and compliance following subarachnoid hemorrhage in dogs. Neurosurgery 37:962-968, 1995
32. Zhang J, Weir BK, Marton LS, Macdonald RL, Bindokas V, Miller RJ, Brorson JR: Mechanisms of hemolysate-induced [Ca++]i elevation in cerebral smooth muscle cells. Am J Physiol 269:H1874-H1890, 1995
33. Kim CJ, Weir B, Macdonald RL, Marton LS, Zhang H: Hemolysate inhibits L-type Ca2+ channels in rat basilar artery smooth muscle cells. J Vasc Res 33:258-264, 1996
34. Mullan S, Mojtahedi S, Johnson DL, Macdonald RL: Embryological basis of some aspects of cerebral vascular fistulas and malformations. J Neurosurg 85:1-8, 1996
35. Mullan S, Mojtahedi S, Johnson DL, Macdonald RL: Cerebral venous malformation-arteriovenous malformation transition forms. J Neurosurg 85:9-13, 1996
36. Alexander TD, Macdonald RL, Weir BKA, Kowalczuk A: Intraoperative angiography in cerebral aneurysm surgery: a prospective study of 100 craniotomies. Neurosurgery 39:10-18, 1996
37. Zhang J, Sima B, Johns LM, Macdonald RL: Time course of changes in endothelium-dependent relaxation following subarachnoid hemorrhage in dogs. Neurol Res 18:227-232, 1996
38. Zhang J, Weir BKA, Macdonald RL, Marton LS, Solenski NJ, Lee KS: Mechanisms of [Ca2+]i elevation induced by erythrocyte components in endothelial cells. J Pharmacol Exp Ther 277:1501-1509, 1996
39. Hino A, Tokuyama Y, Kobayashi M, Yano M, Weir B, Takeda J, Wang X, Bell GI, Macdonald RL: Increased expression of endothelin B receptor mRNA following subarachnoid hemorrhage in monkeys. J Cereb Blood Flow Metab 16:688-697, 1996
40. Ryan MJ, Erickson RK, Levin DN, Pelizzari CA, Macdonald RL, Dohrmann GJ: Frameless stereotaxy with real-time tracking of patient head movement and retrospective patient-image registration. J Neurosurg 85:287-292, 1996
41. Hino A, Tokuyama Y, Weir B, Takeda J, Yano H, Bell GI, Macdonald RL: Changes in endothelial nitric oxide synthase mRNA during vasospasm after subarachnoid hemorrhage in monkeys. Neurosurgery 39:562-568, 1996
42. Kim CJ, Bassiouny M, Macdonald RL, Weir B, Johns LM: Effect of BQ-123 and tissue plasminogen activator on vasospasm after subarachnoid hemorrhage in monkeys. Stroke 27:1629-1633, 1996
43. Sima B, Macdonald RL, Marton LS, Weir B, Zhang J: Effect of P2-purinoceptor antagonists on hemolysate- and ATP-induced contractions of dog basilar artery in vitro. Neurosurgery 39:815-822, 1996
44. Alexander TD, Macdonald RL, Jaffey P: Distal superior cerebellar artery aneurysm surgically treated by a supracerebellar-infratentorial approach. J Neurovasc Dis 1:28-31, 1996
45. Macdonald RL, Fehlings MG, Tator CH, Lozano A, Fleming JR, Gentili F, Bernstein M, Wallace MC, Tasker RR: Multilevel anterior cervical corpectomy and fibular allograft fusion for cervical myelopathy. J Neurosurg 86:990-997, 1997
46. Macdonald RL, Hoffman HJ: Subarachnoid haemorrhage and vasospasm following removal of craniopharyngioma. J Clin Neurosci 4:348-352, 1997
47. Kane J, Macdonald RL, Zhang J, Sima B: HEPES inhibits contractile responses of canine basilar artery. Neurol Res 19:527-533, 1997
48. Sima B, Weir B, Macdonald RL, Zhang H: Extracellular nucleotide-induced [Ca2+]i elevation in rat basilar artery smooth muscle cells. Stroke 28:2053-2059, 1997
49. Macdonald RL, Marton LS, Kowalczuk A, Wang X, Windmeyer E: Effects of hemoglobins on heme oxygenase-1 and viability of cultured smooth muscle cells. Surg Forum 48:534-536, 1997
50. Kowalczuk A, Macdonald RL, Amidei C, Dohrmann GJ, Erickson RK, Hekmatpanah J, Krauss S, Krishnasamy S, Masters G, Mullan SF, Mundt AJ, Sweeney P, Vokes EE, Weir BK, Wollman RL: Quantitative imaging study of extent of surgical resection and prognosis in malignant astrocytoma. Neurosurgery 41:1028-1038, 1997
51. Macdonald RL, Weir B, Marton LS, Zhang J, Sajdak M, Johns LM: Adenosine triphosphate and hemoglobin cause vasospasm in monkeys. Neurosurg Focus 3, 1997 (on line journal)
52. Zhang H, Weir B, Marton L, Lee K, Macdonald RL: P2 purinoceptors in bovine middle cerebral artery endothelial cells mediating the effect of erythrocyte lysate. J Cardiovasc Pharmacol 30:767-774, 1997
53. Macdonald RL, Zhang J, Weir B, Marton LS, Wollman R: Adenosine triphosphate causes vasospasm of the rat femoral artery. Neurosurgery 42:825-833, 1998
54. Kim CJ, Weir BKA, Macdonald RL, Zhang J: Erythrocyte lysate releases Ca2+ from IP3-sensitive stores and activates Ca2+-dependent K+ channels in rat basilar smooth muscle cells. Neurol Res 20:23-30, 1998
55. Macdonald RL, Mojtahedi S, Johns L, Kowalczuk A: Randomized comparison of Guglielmi detachable coils and cellulose acetate polymer for treatment of aneurysms in dogs. Stroke 29:478-486, 1998
56. Macdonald RL, Bassiouny M, Johns L, Sajdak M, Marton LS, Weir BK, Hall ED, Andrus PK: U74389G
prevents vasospasm after subarachnoid hemorrhage in dogs. Neurosurgery 42:1339-1346, 1998
57. Guan YY, Weir B, Marton LS, Macdonald RL, Zhang H: Effects of erythrocyte lysate of different incubation times on intracellular free calcium in rat basilar artery smooth-muscle cells. J Neurosurg 89:1007-1014, 1998
58. International Study of Unruptured Intracranial Aneurysms (ISUIA) Investigators: Unruptured intracranial aneurysms: risk of rupture and risks of surgical intervention. N Engl J Med 339:1725-1733, 1998
59. Macdonald RL, Johns L, Lin G, Marton LS, Hallak H, Marcoux F, Kowalczuk A: Prevention of vasospasm after subarachnoid hemorrhage in dogs by continuous intravenous infusion of PD156707. Neurol Med Chir 38 (Suppl):138-145, 1998
60. Macdonald RL, Weir BK, Marton LS, Windmeyer E, Johns L, Kowalczuk A, Lin G: Heme oxygenase-1 and ferritin proteins are increased in cerebral arteries after subarachnoid hemorrhage in monkeys. Surg Forum 49:501-503, 1998
61. Macdonald RL, Zhang J, Marton LS, Weir B: Effects of cell-permeant calcium chelators on contractility in monkey basilar artery. J Neurotrauma 16:37-47, 1999
62. Citow JS, Macdonald RL: Posterior decompression of the vertebral artery narrowed by cervical osteophyte: case report. Surg Neurol 51:495-498, 1999
63. Wang X, Marton LS, Weir BK, Macdonald RL: Immediate early gene expression in vascular smooth muscle cells synergistically induced by hemolysate components. J Neurosurg 90:1083-1090, 1999
64. Connell PP, Macdonald RL, Mansur DB, Nicholas MK, Mundt AJ: Tumor size predicts for control of benign meningiomas treated with radiation therapy. Neurosurgery 44:1194-1200, 1999
65. Alexander JJ, Lim A, He C, Macdonald RL, Holers VM, Quigg RJ: Renal, central nervous system and pancreatic overexpression of recombinant soluble Crry in transgenic mice. A novel means of protection from complement-mediated injury. Immunopharmacol 42:245-254, 1999
66. Macdonald RL, Amidei C, Lin G, Munshi I, Baron J, Weir B, Brown F, Erickson RK, Hekmatpanah J: Safety of perioperative subcutaneous heparin for prophylaxis of venous thromboembolism in patients undergoing craniotomy. Neurosurgery 45:245-252, 1999
67. Munshi I, Macdonald RL, Weir B: Intraoperative angiography of brain arteriovenous malformations. Neurosurgery 45:491-499, 1999
68. Citow JS, Macdonald RL, Ferguson MK: Combined laminectomy and thoracoscopic resection of a dumbbell neurofibroma: Case report. Neurosurgery 45:1263-1266, 1999
69. Jani AB, Pelizzari CA, Chen GTY, Roeske JC, Hamilton RJ, Macdonald L, Bova F, Hoffmann KR, Sweeney PA: Volume rendering quantification algorithm for reconstruction of CT volume-rendered structures: I. Cerebral arteriovenous malformations. IEEE Transactions on Medical Imaging 19:12-24, 2000
70. Stoodley M, Weihl CC, Zhang ZD, Lin G, Johns LM, Kowalczuk A, Ghadge G, Roos RP, Macdonald RL: Effect of adenoviral-mediated nitric oxide synthase gene transfer on vasospasm after experimental subarachnoid hemorrhage. Neurosurgery 46:1193-1203, 2000
71. Stoodley M, Foroohar M, Macdonald RL, Weir B: Multimedia computer database for neurosurgery. Neurosurgery 47:178-188, 2000
72. Stoodley M, Macdonald RL, Weir B, Marton LS, Johns LM, Zhang ZD, Kowalczuk A: Subarachnoid hemorrhage causes an adaptive response in cerebral arteries. J Neurosurg 93:463-470, 2000
73. Mansur DB, Hekmatpanah J, Wollman R, Macdonald L, Nicholas K, Beckmann E, Mundt AJ: Low grade gliomas treated with adjuvant radiation therapy in the modern imaging era. Am J Clin Oncol 23:222-226, 2000
74. Ono S, Zhang ZD, Marton LS, Yamini B,Windmeyer E, Johns L, Kowalczuk A, Lin G, Macdonald RL: Heme oxygenase-1 and ferritin are increased in cerebral arteries after subarachnoid hemorrhage in monkeys. J Cereb Blood Flow Metab 20:1066-1076, 2000
75. Borsody MK, DeGiovanni GM, Marton LS, Macdonald RL, Weir B: Thrombin reduces cerebral arterial contractions caused by cerebrospinal fluid from patients with subarachnoid hemorrhage. Stroke 31:2149-2156, 2000
76. Macdonald RL, Marton LS, Wang X, Zhang ZD, Sajdak M, Kowalczuk A, Lin G, Windmeyer E: Effects of hemoglobin on heme oxygenase-1 and viability in cultured smooth muscle cells. Am J Physiol 279:H2405-H2413, 2000
77. Lüders JC, Weihl CC, Lin G, Ghadge G, Stoodley M, Roos RP, Macdonald RL: Intrathecal adenoviral gene transfer of nitric oxide synthase increases cerebral blood flow in rats. Neurosurgery 47:1206-1215, 2000
78. Baldwin ZK, Meyerson SL, Skelly CL, McKinsey JF, Bassiouny HS, Macdonald RL, Gewertz BL, Schwartz LB: Estimation du coft actuel de l'endartérectomie carotidienne. Ann Chir Vasc 14:210-215, 2000
79. Foroohar M, Macdonald RL, Roth S, Stoodley M, Weir B: Intraoperative variables and early outcome after aneurysm surgery. Surg Neurol 54:304-315, 2000
80. Lin G, Macdonald RL, Marton LS, Kowalczuk A, Solenski NJ, Weir BK: Hemoglobin increases endothelin-1 in endothelial cells by decreasing nitric oxide. Biochem Biophys Res Comm 280:824-830, 2000
81. Macdonald RL, Weir BKA, Marton LS, Zhang ZD, Sajdak M, Johns LM, Kowalczuk A, Borsody M: The role of adenosine triphosphate in vasospasm after subarachnoid hemorrhage: human investigations. Neurosurgery 48:854-863, 2001
82. Citow JS, Rini B, Wollmann R, Macdonald RL: Isolated, primary extranodal Hodgkin's disease of the spine. Neurosurgery 49:453-457, 2001
83. Yamini B, Macdonald RL, Rosenblum J: Treatment of deep cerebral venous thrombosis by local infusion of tissue plasminogen activator. Surg Neurol 55:240-246, 2001
84. Komuro T, Borsody MK, Ono S, Marton LS, Weir BK, Zhang ZD, Paik E, Macdonald RL: The vasorelaxation of cerebral arteries by carbon monoxide. Experimental Biol Med 225:860-865, 2001
85. Zhang ZD, Yamini, B, Komuro T, Ono S, Johns L, Marton LS, Weir B, Macdonald RL: Vasospasm in monkeys resolves because of loss of and encasement of subarachnoid blood clot. Stroke 32:1868-1874, 2001
86. Le H, Munshi I, Macdonald RL, Wollmann R, Frank J: Traumatic aneurysm from intracranial pressure monitor. J Neurosurg 95:720, 2001
87. Macdonald RL, Zhang ZD, Ono S, Komuro T: Upregulation of parathyroid hormone receptor in cerebral arteries after subarachnoid hemorrhage in monkeys. Neurosurgery 50:1083-1093, 2002
88. Ono S, Komuro T, Weir B, Macdonald RL: Heme oxygenase-1 gene therapy for prevention of vasospasm in rats. J Neurosurg 96:1094-1102, 2002
89. Yassari R, Macdonald RL: Dural arteriovenous fistula after craniotomy for pilocytic astrocytoma in a patient with protein S deficiency. Surg Neurol 58:59-64, 2002
90. Macdonald RL, Zhang ZD, Curry DJ, Elas M, Aihara Y, Halpern H, Jahromi B, Johns L: Intracisternal sodium nitroprusside fails to prevent vasospasm in nonhuman primates. Neurosurgery 51:761-768, 2002
91. Aihara Y, Jahromi BS, Yassari R, Sayama T, Macdonald RL: Effect of nitric oxide donor on and correlation of changes in cyclic nucleotide levels with experimental vasospasm. Neurosurgery 52:661-667, 2003
92. Macdonald RL, Amidei C, Baron J, Weir B, Brown F, Erickson RK, Hekmatpanah J, Frim D: Randomized, double-blind study of dalteparin versus heparin for prevention of venous thromboembolism in patients undergoing craniotomy. Surg Neurol 59:362-371, 2003
93. Torres IJ, Mundt AJ, Sweeney PJ, Llanes-Macy S, Dunaway L, Castillo M, Macdonald RL: A longitudinal neuropsychological study of partial brain radiation in adults with brain tumors. Neurology 60:1113-1118, 2003
94. International Study of Unruptured Intracranial Aneurysms Investigators: Unruptured intracranial aneurysms: natural history, clinical outcome, and risks of surgical and endovascular treatment. Lancet 362:103-110, 2003
95. Macdonald RL, Rosengart A, Huo D, Karrison T: Factors associated with the development of vasospasm after planned surgical treatment of aneurysmal subarachnoid hemorrhage. J Neurosurg 99:644-652, 2003
96. Lee MC, Macdonald RL: Intraoperative cerebral angiography: superficial temporal artery methods and results. Neurosurgery 53:1067-1075, 2003
97. Macdonald RL, Curry D, Aihara Y, Zhang ZD, Jahromi BS, Yassari R: Magnesium and experimental vasospasm. J Neurosurg (in press)
98. Aihara Y, Jahromi BS, Yassari R, Nikitina E, Agbaje-Williams M, Macdonald RL: Molecular profile of vascular ion channels after experimental suabarachnoid hemorrhage. J Cereb Blood Flow Metab (in press)
99. Rosen DS, Macdonald RL: Grading of subarachnoid hemorrhage: A modification of the world federation of neurological surgeons scale based on a large series of patients. Neurosurgery (in press)
Book Chapters:
1. Macdonald RL, Weir BKA, Saito K, Kanamaru K, Findlay JM, Grace M, Runzer T, Mielke B: Hemoglobin and cerebral vasospasm in a monkey model of subarachnoid hemorrhage. In: Sano K, Takakura K, Kassell NF, Sasaki T (eds): Cerebral Vasospasm. Tokyo, University of Tokyo Press, 1990:99-102
2. Weir B, Macdonald L: Cerebral vasospasm. Clinical Neurosurgery: Vol 40:40-55,1993
3. Macdonald RL, Weir BK: Management of vasospasm: tissue plasminogen activator. In: Ratcheson R, Wirth F (eds): Ruptured Cerebral Aneurysms: Perioperative Management. Baltimore, Williams and Wilkins, 1993:168-181
4. Macdonald RL, Wallace, MC, Coyne TJ: Effect of surgery on severity of angiographic vasospasm. In: Findlay JM (ed): Cerebral Vasospasm. Amsterdam, Elsevier, 1993:379-382
5. Coyne TJ, Macdonald RL, Wallace MC: Angiographic vasospasm in the nineties - A continuing phenomenon. In: Findlay JM (ed): Cerebral Vasospasm. Amsterdam, Elsevier, 1993:15-18
6. Coyne TJ, Montanera WJ, Wallace MC, Macdonald RL: Angioplasty for cerebral vasospasm - The Toronto Hospital experience. In: Findlay JM (ed): Cerebral Vasospasm. Amsterdam, Elsevier, 1993:333-336
7. Macdonald RL, Weir BKA: New evidence pointing to oxyhemoglobin as the cause of vasospasm. In: Pasqualin A, Da Pian R (eds): New Trends in Management of Cerebro-Vascular Malformations. Wien, Springer-Verlag, 1994:27-31
8. Macdonald RL, Weir B: Perioperative care of the patient following aneurysmal subarachnoid hemorrhage. In: Schmidek HH, Sweet WH (eds): Operative Neurosurgical Techniques. Indications, Methods, and Results. Philadelphia, Saunders, 3rd edition, 1995:937-955
9. Macdonald RL, Weir B: Pathophysiology and clinical evaluation of subarachnoid hemorrhage. In: Youmans JR (ed): Neurological Surgery. A Comprehensive Reference Guide to the Diagnosis and Management of Neurosurgical Problems. Philadelphia, Saunders, 4th edition, 1995:1224-1242
10. Weir B, Macdonald RL: Management of intracranial aneurysms and arteriovenous malformations during pregnancy. In: Wilkins RH, Rengachary SS (eds): Neurosurgery. New York, McGraw-Hill, 2nd edition, 1996, pp 2191-2214
11. Weir B, Macdonald RL: Intracranial aneurysms and subarachnoid hemorrhage: an overview. In: Wilkins RH, Rengachary SS (eds): Neurosurgery. New York, McGraw-Hill, 2nd edition, 1996, pp 2421-2432
12. Macdonald RL, Weir B: Cerebral vasospasm and delayed cerebral ischemia. In: Tindall GT, Cooper PR, Barrow DL (eds): The Practice of Neurosurgery. Baltimore, Williams and Wilkins, 1996, pp 1969-1988
13. Macdonald RL, Wang X, Zhang J, Marton LS: Molecular changes with subarachnoid hemorrhage and vasospasm. In: Raffel C, Harsh G (eds): The Molecular Biology of Neurosurgical Disease. Baltimore, Williams and Wilkins, 1996, pp 278-293
14. Macdonald RL, Weir BK: Cerebral vasospasm: prevention and treatment. In: Batjer HH, Caplan LR, Friberg L, Greenlee RG Jr, Kopitnik TA, Young WL (eds): Cerebrovascular Disease. New York, Raven Press, 1997, pp 1111-1122
15. Macdonald RL: Surgical management of aneurysms in the pediatric age group. In: Welch KMA, Caplan L, Reis D, Weir B, Siesjo B (eds): Primer on Cerebrovascular Diseases. San Diego, Academic, 1997, pp 484-487
16. Macdonald RL: Unique features of aneurysms by location. In: Welch KMA, Caplan L, Reis D, Weir B, Siesjo B (eds): Primer on Cerebrovascular Diseases. San Diego, Academic, 1997, pp 487-490
17. Macdonald RL: Cerebral vasospasm. In: Welch KMA, Caplan L, Reis D, Weir B, Siesjo B (eds): Primer on Cerebrovascular Diseases. San Diego, Academic, 1997, pp 490-497
18. Macdonald RL, Weir B: Intracranial aneurysms: surgical approach. In: Ginsberg MD, Bogousslavsky J (eds): Cerebrovascular Disease: Pathophysiology, Diagnosis, and Management. Malden, Blackwell Science, 1998, pp 1979-1994
19. Stoodley MA, Macdonald RL, Weir BKA: Pregnancy and Intracranial Aneurysms. In: Le Roux PD, Winn HR (eds): Neurosurgery Clinics of North America. Current Management of Cerebral Aneurysms; Part 1: Evaluation and Perioperative Care. Philadelphia, W.B. Saunders, 1998, pp 549-556
20. Stoodley MA, Macdonald RL, Weir BKA: Surgical Treatment of Middle Cerebral Artery Aneurysms. In: Le Roux PD, Winn HR (eds): Neurosurgery Clinics of North America. Current Management of Cerebral
Aneurysms; Part 2: Techniques of Aneurysm Occlusion. Philadelphia, W.B. Saunders, 1998, pp 823-834
21. Macdonald RL, Johns LM: Developmental Vascular Embryology of the Central Nervous System. In: Jafar JJ, Awad IA, Rosenwasser RH (eds): Vascular Malformations of the Central Nervous System. Philadelphia, Lippincott Williams and Wilkins, 1999, pp 47-60
22. Borsody MK, Macdonald RL: Current Treatment of Cerebral Vasospasm Caused by Subarachnoid Hemorrhage. In: Sinha KK, Chandra P (eds): Advances in Clinical Neurosciences, Volume 9, Catholic Press, Ranchi, 1999, pp 205-222
23. Macdonald RL, Zhang J, Hino A: Characterization of endothelin receptors in monkey basilar artery. In: Dorsch NWC (ed): Cerebral Vasospasm VI. Proceedings of the VIth International Conference on Cerebral Vasospasm. Oslington, Leichhardt, Australia, 1999, pp 2-6
24. Wang X, Macdonald RL, Marton LS, Johns L, Kowalczuk A, Lin G, Windmeyer E, Weir B: Effects of hemoglobin on heme oxygenase-1 in cultured smooth muscle cells. In: Dorsch NWC (ed): Cerebral Vasospasm VI. Proceedings of the VIth International Conference on Cerebral Vasospasm. Oslington, Leichhardt, Australia, 1999, pp 26-30
25. Sima B, Weir BKA, Macdonald RL, Zhang H: P2u receptor mediates the effect of erythrocyte lysate on [Ca2+]i in rat basilar smooth muscle cells. In: Dorsch NWC (ed): Cerebral Vasospasm VI. Proceedings of the VIth International Conference on Cerebral Vasospasm. Oslington, Leichhardt, Australia, 1999, pp 40-42
26. Macdonald RL, Weir B, Zhang J, Marton L, Sajdak M, Johns L: Adenosine triphosphate as a possible cause of vasospasm in monkeys. In: Dorsch NWC (ed): Cerebral Vasospasm VI. Proceedings of the VIth International Conference on Cerebral Vasospasm. Oslington, Leichhardt, Australia, 1999, pp 58-62
27. Macdonald RL, Bassiouny M, Johns L, Sajdak M, Marton LS, Weir BK, Andrus PK, Hall ED: U74389G
prevents vasospasm after subarachnoid hemorrhage in dogs. In: Dorsch NWC (ed): Cerebral Vasospasm VI. Proceedings of the VIth International Conference on Cerebral Vasospasm. Oslington, Leichhardt, Australia, 1999, pp 122-127
28. Macdonald RL,Weir BK: Overview of prevention of vasospasm. In: Dorsch NWC (ed): Cerebral Vasospasm VI. Proceedings of the VIth International Conference on Cerebral Vasospasm. Oslington, Leichhardt, Australia, 1999, pp 386-390
29. Weir BKA, Macdonald RL, Findlay JM, Mielke B, Wollman R: Pathology, Development and Haemodynamics of Cerebral Aneurysms and Arteriovenous Malformations. In: Crockard A, Hayward R, Hoff JT (eds): Neurosurgery. The Scientific Basis of Clinical Practice. Oxford, Blackwell, 2000, pp 675-694
30. Macdonald RL: Gene Therapy for Cerebrovascular Disease and Central Nervous System Trauma. In: Factor PH (ed): Gene Therapy for Acute and Acquired Diseases. Boston, Kluwer, 2000, pp 201-223
31. Macdonald RL: Surgical Treatment of Dural Arteriovenous Malformations and Fistulae. In: Batjer HH, Loftus CM (eds): Textbook of Neurological Surgery. Principles and Practice. Lippincott, Williams and Wilkins, 2003, pp 2517-2529
32. Macdonald RL, Weir B: Perioperative management of subarachnoid hemorrhage. In: Youmans JR (ed): Neurological Surgery. A Comprehensive Reference Guide to the Diagnosis and Management of Neurosurgical Problems. Philadelphia, Saunders, 5th edition, 2003 (in press)
33. Macdonald RL: Cerebral Vasospasm, see Subarachnoid Hemorrhage. In: Aminoff MJ, Daroff RB (eds): Encylopedia of the Neurological Sciences. San Diego, Academic, 2003, pp 627-630
34. Stoodley MA, Macdonald RL, Weir BKA: Aneurysms and Arteriovenous Malformations. In: Asbury AK, McKhann G, McDonald WI, Goadsby PJ, McArthur JC (eds): Diseases of the Nervous System: Clinical Neuroscience and Therapeutic Principles. Cambridge, Cambridge University Press, 3rd edition, 2003 (in press)
35. Jahromi BS, Macdonald RL: Vasospasm: Diagnosis and Medical Management. In: LeRoux PD, Winn HR (eds): Management of Cerebral Aneurysms. WB Saunders, Philadelphia, 2003 (in press)
36. Macdonald RL: What's the Best way to Prevent DVT and PE After Head or Spinal Cord Injury? How Soon After Injury can I Anticoagulate my Patients who Develop DVTs? In: Andrews B, Valadka A (eds): Neurotrauma: Evidence Based Answers to Common Questions. Thieme, New York, 2003 (in press)
37. Weir B, Macdonald RL: Management of Intracranial Aneurysms and Arteriovenous Malformations During Pregnancy. In: Rengachary SS, Maciunas RJ, Wilkins RH (eds): Neurosurgery. McGraw-Hill, New York, 3rd edition, 2003 (in press)
38. Macdonald RL: Cerebral Vasospasm, In: Barnett HJ, Mohr JP, Stein B, Yatsu F, Weir B (eds): Stroke. Pathophysiology, Diagnosis and Management. Churchill Livingstone, New York, 4th edition, 2003 (in press)
39. Macdonald RL, Weir B: Aneurysms and Subarachnoid Hemorrhage: An Overview. In: Rengachary SS, Maciunas RJ, Wilkins RH (eds): Neurosurgery. McGraw-Hill, New York, 3rd edition, 2003 (in press)
40. Macdonald RL: Colloid Cysts in Children. In: Berger MS, Brem H (eds): Textbook of Neuro-Oncology. WB Saunders, Philadelphia, 1st edition, 2003 (in press)
41. Macdonald RL: Molecular Mediators of Hemorrhagic Stroke. In: Janson CG, Freese A (eds): Molecular Neurosurgery. Karger AG, Basel, 2003 (in press)
42. Aihara Y, Jahromi BS, Yassari R, Nikitina E, Agbaje-Williams M, Macdonald RL: Changes in Vascular Ion Channels After Subarachnoid Hemorrhage. In: Macdonald RL (ed): Cerebral Vasospasm. Proceedings of the 8th International Conference. New York, Thieme Medical Publishers, 2003 (in press)
43. Jahromi BS, Aihara Y, Agbaje-Williams M, Nikitina E, Weyer G, Ryan D, Yassari R, Macdonald RL: Potassium Channels in Experimental Cerebral Vasospasm. In: Macdonald RL (ed): Cerebral Vasospasm. Proceedings of the 8th International Conference. New York, Thieme Medical Publishers, 2003 (in press)
44. Rosen DS, Macdonald RL: Grading Scale for Subarachnoid Hemorrhage Based on a Modification of The World Federation of Neurological Surgeons Scale. In: Macdonald RL (ed): Cerebral Vasospasm. Proceedings of the 8th International Conference. New York, Thieme Medical Publishers, 2003 (in press)
Books:
1. Citow JS, Macdonald RL, Kraig RP, Wollmann RL: Comprehensive Neurosurgery Board Review. New York, Thieme Medical Publishers, 2000, pp 1-511
2. Macdonald RL, Weir B: Cerebral Vasospasm. San Diego, Academic Press, 2001, pp 1-518
3. Citow JS, Wollmann RL, Macdonald RL: Neuropathology and Neuroradiology. A Review. New York, Thieme Medical Publishers, 2001, pp 1-239
4. Citow JS, Macdonald RL: Neuroanatomy and Neurophysiology. A Review. New York, Thieme Medical Publishers, 2001, pp 1-181
5. Macdonald RL (ed): Cerebral Vasospasm. Proceedings of the 8th International Conference. New York, Thieme Medical Publishers, 2003 (in press)
Reviews and Invited Papers:
1. Macdonald RL, Weir BKA: A review of hemoglobin and the pathogenesis of cerebral vasospasm. Stroke 22:971-982, 1991
2. Findlay JM, Macdonald RL, Weir BKA: Current concepts on pathophysiology and management of cerebral vasospasm following aneurysmal subarachnoid hemorrhage. Cerebrovascular Brain Metab Rev 3:336-361, 1991
3. Macdonald RL, Weir BKA: Free radicals and vasospasm. Free Radical Biol Med 16:633-644, 1994
4. Macdonald RL, Cogen PH, Weir B: Midline vascular lesions. Contemporary Neurosurgery 16:24-28, 1994
5. Macdonald RL: Cerebral Vasospasm. Neurosurgery Quarterly 5:73-97, 1995
6. Macdonald RL: Drug treatment of aneurysmal subarachnoid haemorrhage. CNS Drugs 5:264-277, 1996
7. Macdonald RL: Controversies in the management of carotid stenosis. J Neurosci Nursing 28:93-98, 1996
8. Macdonald RL: Aneurysms and subarachnoid hemorrhage. New Develop Med Drug Ther 5:49-51, 1996
9. Macdonald RL, Stoodley MA: Pathophysiology of cerebral ischemia. Neurol Med Chir (Tokyo) 38:1-11, 1998
10. Weihl C, Macdonald RL, Stoodley M, Lüders J, Lin G, Ghadge G, Roos R: Gene therapy for cerebrovascular disease. Neurosurgery 44:239-253, 1999
11. Weir B, Macdonald RL, Stoodley MA: Etiology of cerebral vasospasm. Acta Neurochir Suppl 72:27-46, 1999
12. Macdonald RL, Stoodley M, Weir B: Intracranial aneurysms. Neurosurg Quart 11:181-198, 2001
13. Macdonald RL, Stoodley M, Weir B: Vascular malformations of the central nervous system. Neurosurg Quart 11:231-247, 2001
14. Macdonald RL: Pathophysiology and molecular genetics of vasospasm. Acta Neurochir 77 (Suppl):7-11, 2001
15. Zhang ZD, Yamini B, Komuro T, Ono S, Johns L, Marton LS, Weir B, Macdonald RL: Delayed clot removal and experimental vasospasm. Acta Neurochir 77 (Suppl):33-35, 2001
16. Macdonald RL, Ono S, Johns L, Marton LS, Weir B, Zhang ZD, Yamini B, Komuro T, Ahmed I, Stoodley M: Molecular weight interactions in experimental vasospasm. Acta Neurochir 77 (Suppl):115-117, 2001
17. Jahromi B, Komuro T, Macdonald RL, Marton LS, Weir BK: Phosphatidylcholine peroxidized by hemoglobin increases intracellular calcium in dog basilar artery smooth muscle cells. Acta Neurochir 77 (Suppl):45-47, 2001
18. Ono S, Komuro T, Macdonald RL: Adenovirus-mediated heme oxygenase-1 gene transfection prevents hemoglobin-induced contraction of rat basilar artery. Acta Neurochir 77 (Suppl):93-96, 2001
19. Zhang ZD, Marton LS, Ono S, Komuro T, Weir B, Macdonald RL: Complimentary deoxyribonucleic acid array analysis of cerebral arteries after experimental subarachnoid hemorrhage. Acta Neurochir 77 (Suppl):17-19, 2001
Published Abstracts and Editorial Comments:
1. Macdonald RL, Muller PJ, Tucker WS, Moulton RJ, Hudson AR: Petrous meningiomas: A review of seventeen cases. Can J Neurol Sci 15:184-185, 1988 (abstract)
2. Macdonald RL, Weir BKA, Saito K, Kanamaru K, Findlay JM, Grace MG: Intrathecal injections of oxyhemoglobin and bilirubin cause cerebral vasospasm in primates. Can J Neurol Sci 17:239, 1990 (abstract)
3. Macdonald RL, Weir BKA, Chen M: Scanning electron microscopy of normal and vasospastic monkey cerebrovascular smooth muscle cells. Stroke 22:145, 1991 (abstract)
4. Runzer TD, Weir BKA, Macdonald RL: Lipid peroxidation and cerebral vasospasm. Stroke 22:146, 1991 (abstract)
5. Findlay JM, Macdonald RL, Weir BKA, Grace MG: Effect of operation on established cerebral vasospasm. Stroke 22:146, 1991 (abstract)
6. Macdonald RL, Weir BKA, Runzer TD, Grace MG, Findlay JM: Oxyhemoglobin and cerebral vasospasm in monkeys. J Neurosurg 74:354A, 1991 (abstract)
7. Takanashi Y, Weir BKA, Vollrath B, Kasuya H, Macdonald RL: Intracellular free calcium concentration and contractile protein change in cultured vascular smooth muscle cells following prolonged exposure to oxyhemoglobin. Can J Neurol Sci 18:209, 1991 ()
8. Findlay JM, Macdonald RL, Weir BKA, Grace MGA: Effect of surgical manipulation on primate cerebral arteries in established vasospasm. Can J Neurol Sci 18:208, 1991 (abstract)
9. Macdonald RL, Weir BKA, Runzer TD, Grace MGA, Poznansky M: Effect of intrathecal superoxide dismutase and catalase on oxyhemoglobin-induced vasospasm in monkeys. J Neurosurg 76:394A, 1992 (abstract)
10. Macdonald RL, Weir BKA: Oxyhemoglobin-induced vasospasm (letter to the editor). J Neurosurg 76:726, 1992
11. Macdonald RL, Wallace MC: Role of angiography following aneurysm surgery. Can J Neurol Sci 19:254, 1992 (abstract)
12. Macdonald RL, Weir BKA: Comparability of vasospasm in primates (letter to the editor). J Neurosurg 77:329, 1992
13. Macdonald RL, Wallace, MC, Coyne TJ: Effect of surgery on severity of angiographic vasospasm. Can J Neurol Sci Suppl 1:S27, 1993 (abstract)
14. Coyne TJ, Macdonald RL, Wallace MC: Angiographic vasospasm in the nineties - A continuing phenomenon. Can J Neurol Sci Suppl 1:S3, 1993 (abstract)
15. Coyne TJ, Montanera WJ, Wallace MC, Macdonald RL: Angioplasty for cerebral vasospasm - The Toronto Hospital experience. Can J Neurol Sci Suppl 1:S24, 1993 (abstract)
16. Humphreys RP, Macdonald RL, Rutka JT, Kestle JRW: The III ventricular colloid cyst in children. Child's Nerv Syst 9:364, 1993 (abstract)
17. Macdonald RL, Montanera WJ, Wallace MC, Han H: Effect of transluminal angioplasty on vasospastic rabbit carotid arteries. Stroke 25:268, 1994 (abstract)
18. Macdonald RL, Wallace C, Kestle JRW: Inraoperative angiography (letter to the editor). J Neurosurg 81:336, 1994
19. Macdonald RL, Zhang J, Kane J: Effects of an intracellular calcium chelator on smooth muscle contraction in vitro. Stroke 26:182, 1995
20. Macdonald RL, Kowalczyk A, Johns L: Small emboli can cause lacunar infarcts in primate brain. Stroke 26:183, 1995
21. Macdonald RL, Wallace MC: Surgery and vasospasm (letter to the editor). J Neurosurg 82:146-147, 1995
22. Macdonald RL: Book review (The Human Brain Circulation: Functional Changes in Disease). Surg Neurol 43:304-305, 1995
23. Macdonald RL: Editorial comment. Neurosurgery 37:638-639, 1995
24. Macdonald RL: Editorial comment. Surg Neurol 44:170, 1995
25. Chen Y, Hoffmann KR, Macdonald RL, Hackworth CA, Doi K: Comparison of techniques for measurement of vessel sizes in angiograms. Med Phys 22:936, 1995 (abstract)
26. Macdonald RL: Editorial comment. Neurosurgery 38:787, 1996
27. Macdonald RL: Editorial comment. Neurosurgery 39:997, 1996
28. Macdonald RL: Editorial comment. Stroke 27:2094, 1996
29. Macdonald RL: Editorial comment. Stroke 28:403-404, 1997
30. Macdonald RL: Editorial comment. Neurosurgery 40:160-161, 1997
31. Macdonald RL: Editorial comment. Neurosurgery 40:351-352, 1997
32. Alexander T, Macdonald RL, Weir B: Intraoperative angiography in cerebral aneurysm surgery: A prospective study of 100 craniotomies. Neurosurgery 40:1108, 1997 (abstract)
33. Macdonald RL: Editorial comment. Neurosurgery 41:1357-1358, 1997
34. Macdonald RL: Editorial comment. Neurosurgery 41:1391-1392, 1997
35. Macdonald RL, Bassiouny M, Johns L, Sajdak M, Marton LS, Weir BK, Hall ED, Andrus PK: U74389G prevents vasospasm after subarachnoid hemorrhage in dogs. J Neurosurg 88:200A, 1998 (abstract)
36. Macdonald RL: Editorial comment. Neurosurgery 42:351, 1998
37. Macdonald RL: Editorial comment. Stroke 29:1018-1019, 1998
38. Macdonald RL: Editorial comment. Neurosurgery 42:1082, 1998
39. Macdonald RL: Editorial comment. Stroke 29:1922-1923, 1998
40. Macdonald RL: Editorial comment. Stroke 29:1935-1936, 1998
41. Macdonald RL, Ghadge G, Weihl C, Stoodley M, Johns LS, Lin G, Kowalczuk A, Roos R: Effect of adenoviral nitric oxide synthase gene transfer on vasospasm after subarachnoid hemorrhage. Neurosurgery 43:720, 1998 (abstract)
42. Macdonald RL: Editorial comment. Stroke 29:2140, 1998
43. Macdonald RL, Bassiouny M, Johns L, Sajdak M, Marton LS, Weir BK, Hall ED, Andrus PK: U74389G prevents vasospasm after subarachnoid hemorrhage in dogs. Stroke 29:2216, 1998 (abstract)
44. Macdonald RL: Editorial comment. Neurosurgery 43:1079-1080, 1998
45. Macdonald RL: Editorial comment. Stroke 29:2434, 1998
46. Macdonald RL, Zhang J, Marton LS, Weir B, Johns L, Guan YY, Stoodley MS, Kowalczuk A: Spasmogens and cerebral vasospasm. J Vasc Res 35 (Suppl 3):17, 1998 (Abstract)
47. Zhang J, Sima B, Macdonald RL, Weir B: P2 receptors in cerebral arteries. J Vasc Res 35 (Suppl 3):26, 1998 (Abstract)
48. Stoodley MS, Macdonald RL, Weir B, Marton LS, Johns L, Sajdak M, Zhang J, Kowalczuk A: Vasospasm depends on the presence of subarachnoid clot for a minimum of 3 days. J Neurosurg: Spine 90:227A, 1999 (Abstract)
49. Macdonald RL: Editorial comment. Neurosurgery 44:377-378, 1999
50. Macdonald RL: Editorial comment. Stroke 30:455-456, 1999
51. Macdonald RL: Editorial comment. Stroke 30:650, 1999
52. Macdonald RL, Weir B: Editorial comment. Surg Neurol 51:392-398, 1999
53. Macdonald RL: Molecular and biological basis of arterial vasospasm due to SAH. Interventional Neuroradiol 5 (Suppl 1):30-31, 1999 (Abstract)
54. Macdonald RL: Editorial comment. Stroke 30:1255, 1999
55. Macdonald RL: Editorial comment. Neurosurgery 45:39, 1999
56. Macdonald RL: Editorial comment. Neurosurgery 45:345, 1999
57. Macdonald RL: Editorial comment. Neurosurgery 45:848, 1999
58. Macdonald RL: Editorial comment. Neurosurgery 45:969, 1999
59. Macdonald RL: Editorial comment. Stroke 30:2477-2478, 1999
60. Macdonald RL: Editorial comment. Surg Neurol 51:521-527, 1999
61. Macdonald RL: Editorial comment. Stroke 31:174-175, 2000
62. Foroohar M, Macdonald RL, Roth S, Stoodley M, Weir B: Influence of intraoperative variables on outcome after aneurysm surgery. J Neurosurg 92:207, 2000 (Abstr)
63. Macdonald RL, Ono S, Zhang ZD, Marton L, Yamini B: Induction of heme oxygenase and ferritin in cerebral arteries after SAH in monkeys. J Neurosurg 92:209-210, 2000 (Abstr)
64. Macdonald RL, Weir B, Marton LS, Zhang ZD, Sajdak M, Johns LM, Kowalczuk A, Borsody M: Role of adenosine triphosphate in vasospasm: investigations in humans. J Neurosurg 92:227, 2000 (abstract)
65. Macdonald RL: Editorial comment. Neurosurgery 46: 447, 2000
66. Munshi I, Macdonald RL, Weir B: Intraoperative angiography of brain AVMs. J Neurosurg 92:569-570, 2000 (abstract)
67. Macdonald RL: Editorial comment. Neurosurgery 46:601-602, 2000
68. Macdonald RL: Editorial comment. Neurosurgery 46:916, 2000
69. Macdonald RL: Editorial comment. Neurosurgery 46:932, 2000
70. Macdonald RL: Editorial comment. Neurosurgery 46:1279, 2000
71. Macdonald RL: Editorial Comment. Stroke 31:1142-1143, 2000
72. Macdonald RL: Editorial Comment. Stroke 31:1384-1385, 2000
73. Macdonald RL: Editorial comment. Neurosurgery 47:71-72, 2000
74. Macdonald RL: Editorial comment. Neurosurgery 47:215, 2000
75. Macdonald RL: Editorial comment. Neurosurgery 47:600, 2000
76. Macdonald RL: Editorial comment. Neurosurgery 47:709, 2000
77. Stoodley M, Weihl CC, Zhang ZD, Lin G, Johns LM, Kowalczuk A, Ghadge G, Roos RP, Macdonald RL: Effect of adenoviral-mediated nitric oxide synthase gene transfer on vasospasm after experimental subarachnoid hemorrhage. Stroke 31:2280-2281, 2000 (abstract)
78. Macdonald RL: Editorial comment. Neurosurgery 47:855-856, 2000
79. Macdonald RL: Editorial comment. Neurosurgery 47:908, 2000
80. Macdonald RL: Editorial comment. Stroke 31:2458-2459, 2000
81. Macdonald RL: Editorial comment. Neurosurgery 47:1128, 2000
82. Macdonald RL: Editorial comment. Neurosurgery 47:1233, 2000
83. Macdonald RL: Editorial comment. Neurosurgery 47:1419, 2000
84. Ono S, Komuro T, Weir B, Macdonald RL: Heme oxygenase-1 gene therapy for prevention of vasospasm in rats. J Neurosurg 94:159A, 2001 (abstract)
85. Macdonald RL: Editorial comment. Stroke 32:231, 2001
86. Ono S, Macdonald RL: Heme oxygenase-1 gene therapy for prevention of vasospasm in rats. Stroke 32:330, 2001 (abstract)
87. Macdonald RL: Editorial comment. Neurosurgery 48:634, 2001
88. Macdonald RL: Editorial comment. Neurosurgery 48:728-729, 2001
89. Macdonald RL: Editorial comment. Neurosurgery 48:892-893, 2001
90. Macdonald RL: Editorial comment. Neurosurgery 48:901, 2001
91. Macdonald RL: Editorial comment. Neurosurgery 48:909-910, 2001
92. Macdonald RL: Editorial comment. Neurosurgery 48:932, 2001
93. Macdonald RL: Editorial comment. Neurosurgery 48:1010, 2001
94. Macdonald RL: Editorial comment. Neurosurgery 48:1333-1334, 2001
95. Macdonald RL: Editorial comment. Neurosurgery 48:1342-1343, 2001
96. Macdonald RL: Editorial comment. Neurosurgery 49:39-40, 2001
97. Macdonald RL: Editorial comment. Neurosurgery 49:166-167, 2001
98. Macdonald RL, Zhang ZD, Weir B, Yamini B, Curry D: Role of NO in vasospasm after experimental subarachnoid hemorrhage. J Vasc Res 38 (Suppl 2):22, 2001 (abstract)
99. Macdonald RL: Editorial comment. Neurosurgery 49:428-429, 2001
100. Macdonald RL: Editorial comment. Stroke 32:1656-1657, 2001
101. Macdonald RL: Editorial comment. Neurosurgery 49:1222, 2001
102. Macdonald RL: Editorial comment. Neurosurgery 49:1349-1350, 2001
103. Macdonald RL: Editorial comment. Neurosurgery 49:1441, 2001
104. Macdonald RL: Editorial comment. Neurosurgery 49:1450-1451, 2001
105. Macdonald RL: Editorial comment. Neurosurgery 50:135, 2002
106. Macdonald RL: Editorial comment. Neurosurgery 50:174, 2002
107. Macdonald RL: Editorial comment. Neurosurgery 50:295, 2002
108. Macdonald RL: Editorial comment. Neurosurgery 50:377-378, 2002
109. Rosengart A, Macdonald RL, Weir B: Prognostic factors for outcome and clinical grading of aneurysmal SAH based on metaanalysis of the tirilazad database. J Neurosurg 96: 172A, 2002 (abstract)
110. Macdonald RL, Zhang ZD, Curry D, Aihara Y, Jahromi B: Sodium nitroprusside does not prevent experimental vasospasm. J Neurosurg 96: 187A-188A, 2002 (abstract)
111. Rosengart A, Macdonald RL, Weir B: Metaanalysis of the effect of tirilazad on outcome and vasospasm after aneurysmal SAH. J Neurosurg 96: 188A, 2002 (abstract)
112. Macdonald RL: Editorial comment. Neurosurgery 50:598, 2002
113. Macdonald RL: Editorial comment. Neurosurgery 50:688, 2002
114. Macdonald RL: Editorial comment. Neurosurgery 50:755-756, 2002
115. Macdonald RL: Editorial comment. Neurosurgery 50:848, 2002
116. Macdonald RL: Editorial comment. Neurosurgery 50:1030, 2002
117. Macdonald RL: Editorial comment. Neurosurgery 50:1222, 2002
118. Macdonald RL: Editorial comment. Neurosurgery 50:1229, 2002
119. Ono S, Komuro T, Macdonald RL: Editorial response. J Neurosurg 96:986-987, 2002
120. Macdonald RL: Editorial comment. Neurosurgery 51:210-211, 2002
121. Aihara Y, Jahromi BS, Yassari R, Sayama T, Macdonald RL: Effect of a nitric oxide donor on experimental vasospasm. Neurosurgery 51:579, 2002 (abstract)
122. Macdonald RL: Editorial comment. Neurosurgery 51:948, 2002
123. Macdonald RL: Editorial comment. Neurosurgery 51:1003-1004, 2002
124. Macdonald RL: Editorial comment. Neurosurgery 51:1041, 2002
125. Macdonald RL: Editorial comment. Neurosurgery 51:1273-1274, 2002
126. Macdonald RL: Editorial comment. Neurosurgery 51:1422, 2002
127. Macdonald RL: Editorial comment. Neurosurgery 51:1465-1466, 2002
128. Macdonald RL: Editorial comment. Neurosurgery 51:1474-1475, 2002
129. Macdonald RL: Editorial comment. Neurosurgery 52:139, 2003
130. Macdonald RL, Aihara Y, Jahromi BS, Yassari R: Effect of a nitric oxide donor on experimental vasospasm in nonhuman primates. Stroke 34:277, 2003 (abstract)
131. Macdonald RL: Intraoperative angiography via the superficial temporal artery. J Neurosurg 98:238A, 2003 (abstract)
132. Macdonald RL: Editorial comment. Neurosurgery 52:968, 2003
133. Macdonald RL: Editorial comment. Neurosurgery 52:1031, 2003
134. Macdonald RL: Editorial comment. Neurosurgery 52:1194-1195, 2003
135. Macdonald RL: Editorial comment. Neurosurgery 53:134, 2003
136. Macdonald RL: Editorial comment. Neurosurgery 53:190-191, 2003
137. Jahromi BS, Aihara Y, Agbaje-Williams M, Nikitina E, Weyer G, Ryan D, Yassari R, Macdonald RL: Voltage-gated potassium channels are down-regulated in experimental cerebral vasospasm. Neurosurgery 53:470, 2003
138. Macdonald RL: Editorial comment. Neurosurgery 53:1066, 2003
139. Macdonald RL: Editorial comment. Neurosurgery 53:1187, 2003
140. Macdonald RL: Editorial comment. Neurosurgery 53:1214, 2003
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